Can serum NSE and S100-beta protein levels predict central nervous system injury in patients with carbon dioxide retention?

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dc.contributor.authorGunes, Harun
dc.contributor.authorCandar, Muhammed M.
dc.contributor.authorSaritas, Ayhan
dc.date.accessioned2021-12-01T18:47:23Z
dc.date.available2021-12-01T18:47:23Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjectives: To evaluate whether serum neuron specific enolase (NSE) or S100-beta protein levels are helpful in predicting central nervous system (CNS) injury in patients with carbon dioxide (CO2) retention Design: A case-control study Setting: This study was performed in the Emergency Department of a University Hospital which functions as the only tertiary center in the city. Subjects: One hundred patients who were admitted to the emergency department and seen to have an arterial partial carbon dioxide pressure above 45 mmHg were included as the study group and 48 healthy volunteers as the control group. Interventions: None Main outcome measures: Possible elevations in serum NSE and/or S100-beta protein levels in the study group were main outcome measures. The levels of these markers were measured using enzyme-linked immunoassay kits, and mean values of these parameters were compared between the study and the control groups. Results: Mean NSE level was found to be 69.45 +/- 36.39 ng/ml, and mean S100-beta level was 160.57 +/- 54.05 pg/ml in the study group. Mean NSE and S100-beta levels of the control group were 30.99 +/- 20.04 ng/ml and 129.31 +/- 415.17 pg/ml, respectively. Mean NSE levels differed significantly between the study and control groups; however, mean S100-beta levels did not. Conclusions: The results of the present study suggest that NSE can be used to predict CNS injury in patients with CO2 retention, but S100-beta protein cannot. New studies including larger number of patients are needed to obtain more accurate results on this topic.en_US
dc.description.sponsorshipScientific Research Projects Foundation of Duzce UniversityDuzce Universityen_US
dc.description.sponsorshipWe would like to thank the Scientific Research Projects Foundation of Duzce University for their financial support to the study.en_US
dc.identifier.endpage168en_US
dc.identifier.issn0023-5776
dc.identifier.issue2en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10253
dc.identifier.volume52en_US
dc.identifier.wosWOS:000540762300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarbon dioxide retentionen_US
dc.subjectcentral nervous system injuryen_US
dc.subjecthypercapniaen_US
dc.subjectneuron-specific enolaseen_US
dc.subjectS100-betaen_US
dc.subjectNeuron-Specific Enolaseen_US
dc.subjectBrainen_US
dc.subjectIndicatoren_US
dc.subjectS-100en_US
dc.subjectCsfen_US
dc.titleCan serum NSE and S100-beta protein levels predict central nervous system injury in patients with carbon dioxide retention?en_US
dc.typeArticleen_US

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