Carotis intima media thickness in female patiens with subclinical hypothyroidism [Subklinik hipotiroidili kadin hastalarda karotis intima media kalinli?i]

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dc.contributor.authorÖnder, Elif
dc.contributor.authorAydın, Yusuf
dc.contributor.authorGüngör, Adem
dc.contributor.authorCelbek, Gökhan
dc.contributor.authorKır, Seher
dc.contributor.authorYıldırım, Hayriye Ak
dc.contributor.authorCinemre, Hakan
dc.date.accessioned2020-04-30T13:32:11Z
dc.date.available2020-04-30T13:32:11Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Recent studies have shown that subclinical hypothyroidism (SCH) has similar cardiovascular risks with clinical hypothyroidism (CH). We evaluated carotis intima media thickness (CIMT)-indicator of early changes in atherosclerotic process- in female patients, who have either CH or SCH, with similar age and demographic features. Materials and Methods: In this study, we included 81 female patients admitted to internal medicine and endocrinology outpatient clinic, diagnosed with CH (30) or SCH (51) according to their laboratory findings and who have not previously received treatment and 38 healthy women. BMI (body mass index), sistolic and diastolic blood pressure, triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), vitamin B-12, folate, homocysteine, high-sensitive C-reactive protein (Hs CRP), and CIMT were measured in all participants. Results: There was not a statistical difference between the groups in TG, TC, HDL-C, LDL-C, vitamin B-12, and folate levels (p>0.05). On the other hand, SCH and CH groups differed statistically significantly from the control group for Hs CRP (p=0.011), homocysteine (p<0.001), and CIMT values. Additionally, age was found to be the most important factor for increase in CIMT when multiple linear regression analysis was performed. Conclusions: Lack of difference between CH patients and SCH patients in respect to Hs CRP, homocystein, and CIMT shows that inflammation and increase in CIMT starts during SCH period. Hence, we think that the increase in CIMT in SCH patients when TSH levels are higher than the normal range is a clinically important sign of early cardiovascular diseases.en_US
dc.identifier.endpage94en_US
dc.identifier.issn1301-2193
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/138
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosis; Carotis intima media thickness; Clinical hypothyroidism; Subclinical hypothyroidismen_US
dc.titleCarotis intima media thickness in female patiens with subclinical hypothyroidism [Subklinik hipotiroidili kadin hastalarda karotis intima media kalinli?i]en_US
dc.typeArticleen_US

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