Have the reference ranges of anemia parameters like iron, ferritin, vitamin B-12 and folate been correctly settled in Turkish adults living in western Black Sea Region?

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dc.contributor.authorDemirin, Hilmi
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorUçgun, Taner
dc.contributor.authorYıldırım, Hayriye Ak
dc.contributor.authorÇeler, Ahmet
dc.contributor.authorBulur, Şule
dc.contributor.authorGüneş, Cemalettin
dc.date.accessioned2020-05-01T12:10:17Z
dc.date.available2020-05-01T12:10:17Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000314289700003en_US
dc.description.abstractObjective: Widespread causes of anemia are the deficiencies of iron, vitamin B-12 and folate. The exact diagnosis is based on the laboratory data determined according to the appropriate reference ranges along with clinical symptoms. International Federation of Clinical Chemistry (IFCC) and Clinical and Laboratory Standards Institute (CLSI) have suggested that each laboratory should determine their own reference values. In this study, we aim to determine reference intervals of anemia parameters in a large cohort of Turkish adults and to investigate whether these values confirm with data sheets of commercial kits. Methods: Healthy 1251 subjects were included in the study. Subjects were divided into six groups according to their ages. Levels of serum iron, unsaturated iron binding capacity (UIBC), ferritin, vitamin B-12 and folate, and complete blood counts of all participants were determined. Results: There were significant differences between genders in terms of serum iron, ferritin, UIBC, folate levels and mean corpuscular volume (MCV). While levels of iron, UIBC, ferritin, and MCV were higher in males, vitamin B-12 and folate levels were higher in females. MCV, folate and vitamin B-12 levels were higher in middle aged adults, and lower in the young and elderly. Conclusion: There wasn't much difference between our results and previous studies and manufacturers' ranges except the ferritin and iron levels. Therefore, reference ranges are not required to be determined again. It was concluded that, high upper limits of serum iron and ferritin levels may be caused by inflammation so that these levels is not appropriate as a reference range unless evaluated together with inflammatory markers such as CRP, but lower levels may be valuable.en_US
dc.identifier.doi10.5505/tjb.2012.73645en_US
dc.identifier.endpage361en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.startpage356en_US
dc.identifier.urihttps://doi.org/10.5505/tjb.2012.73645
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6127
dc.identifier.volume37en_US
dc.identifier.wosWOS:000314289700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnemiaen_US
dc.subjectreference rangeen_US
dc.subjectvitamin B-12en_US
dc.subjectfolateen_US
dc.subjectIronen_US
dc.subjectUIBCen_US
dc.titleHave the reference ranges of anemia parameters like iron, ferritin, vitamin B-12 and folate been correctly settled in Turkish adults living in western Black Sea Region?en_US
dc.typeArticleen_US

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