Reciprocal Effects of Adipose Tissue Denervation and High Fat Diet on Serum Metabolic Parameters and Adipokine Levels in Rats: A Long Term Study

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dc.authoridALVER, AHMET/0000-0002-9617-6689
dc.authoridabidin, ismail/0000-0003-2510-9718
dc.authorwosidALVER, AHMET/GQA-9100-2022
dc.authorwosidALVER, AHMET/AAH-4599-2021
dc.contributor.authorKahraman, Cemil
dc.contributor.authorRendi, T. Ahmadi
dc.contributor.authorSağlam, Neslihan
dc.contributor.authorAkça, İmran İnce
dc.contributor.authorAbidin, İsmail
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2023-07-26T11:51:08Z
dc.date.available2023-07-26T11:51:08Z
dc.date.issued2022
dc.departmentDÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractThe sympathetic nervous system (SNS) plays an important role in regulating the metabolic and secretory functions of white adipose tissue. In this study, it was aimed to investigate the long term effects of bilateral retroperitoneal adipose tissue denervation and high fat diet (HFD) on general metabolic status and serum levels of some adipokines in rats. For this purpose, we fed denervated and control rats with control and high fat diet for 70 days. At the end of the feeding program, denervation caused an increase in serum triglyceride (p < 0.01), leptin (p < 0.05) and adiponectin levels (p < 0.01), as well as body weight (p < 0.05) in the group with the control diet (CD). We also observed that the serum adiponectin levels (p < 0.05), of the animals in the denervated HFD group was higher than the non-denervated group whereas the body weight and leptin/adiponectin ratio were reduced. Our data indicate that bilateral denervation of a pad of white adipose tissue in rats causes different changes in metabolic parameters and circulating adipokine levels at different energy states, and in the long term, while denervation mimicked obesity in the control diet group, it to some extent suppressed the effects of a high fat diet in the HFD group.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S147]en_US
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (114S147).en_US
dc.identifier.doi10.1134/S0022093022020090
dc.identifier.endpage417en_US
dc.identifier.issn0022-0930
dc.identifier.issn1608-3202
dc.identifier.issue2en_US
dc.identifier.startpage410en_US
dc.identifier.urihttps://doi.org/10.1134/S0022093022020090
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12499
dc.identifier.volume58en_US
dc.identifier.wosWOS:000796544500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKahraman, Cemil
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofJournal of Evolutionary Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAdipose Tissue; Adipokines; Bilateral Denervation; Body Weight; High Fat Diet; Insulin; Leptin; Norepinephrine; Resistin; Triglyceridesen_US
dc.subjectInsulin-Resistance; White; Adiponectin; Innervation; Expressionen_US
dc.titleReciprocal Effects of Adipose Tissue Denervation and High Fat Diet on Serum Metabolic Parameters and Adipokine Levels in Rats: A Long Term Studyen_US
dc.typeArticleen_US

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