The role of ferroptotic cell death-related HMGB1 in inflammation crosstalk with cancer and myocardial Ischemia/reperfusion injury

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dc.authorscopusid55515395600
dc.authorscopusid6602873428
dc.authorscopusid36543258600
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorGüven, Celal
dc.contributor.authorTaşkın, E.
dc.date.accessioned2023-07-26T11:57:32Z
dc.date.available2023-07-26T11:57:32Z
dc.date.issued2022
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractInflammation is one of the critical defense pathways against pathogen and pathologic conditions, including cancer and myocardial ischemia/ reperfusion (MIR) injury. Therefore, inflammation has positive and negative impacts on tissues and organs. There are two types of inflammation, named as acute and chronic inflammation. The inflammation is also involved in the development of cancer and myocardial infarction. Damage-associated molecular patterns (DAMPs), such as High Mobility Group Box-1 (HMGB1), heat shock proteins (HSPs), ATP, and S100 proteins, are conservative danger molecules released from damaged or dying cells to trigger an immune response. However, they have essential roles in pathological inflammation to participate in self-defense in physiological and pathological circumstances. Recent evidence has emerged that inflammation may be a significant factor in the development and/or progression of cancer and myocardial infarction. Herein, we review current research on the role of HMGB1 in cancer and myocardial ischemia/reperfusion injury, focusing on inflammation. Furthermore, we have discussed the role of the posttranslational modification of HMGB1 in both illnesses. In addition, we focus on a new cell death pathway named ferroptosis, which may be involved in the development of both cancer and MIR through inflammation by HMGB1. © 2023 by Nova Science Publishers, Inc. All rights reserved.en_US
dc.identifier.endpage74en_US
dc.identifier.isbn9798886974669
dc.identifier.isbn9798886974089
dc.identifier.scopus2-s2.0-85143993339en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13218
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaya, Salih Tunç
dc.language.isoenen_US
dc.publisherNova Science Publishers, Inc.en_US
dc.relation.ispartofHMGB1: Functions, Inhibitors and Clinical Significanceen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectCanceren_US
dc.subjectFerroptosisen_US
dc.subjectHigh mobility group box-1en_US
dc.subjectInflammationen_US
dc.subjectMyocardial ischemia/reperfusion injuryen_US
dc.subjectPosttranslational modificationen_US
dc.titleThe role of ferroptotic cell death-related HMGB1 in inflammation crosstalk with cancer and myocardial Ischemia/reperfusion injuryen_US
dc.typeBook Chapteren_US

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