Comparison of the effects of 3 different anti-VEGF drugs on cornea thickness, lens thickness and anterior chamber depth: Case-Control Study

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dc.contributor.authorEski, Mehmet Tahir
dc.contributor.authorTeberik, Kuddusi
dc.contributor.authorSezer, Taha
dc.date.accessioned2024-08-23T16:07:44Z
dc.date.available2024-08-23T16:07:44Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractTo compare the long-term effects of 3 different anti-VEGF molecules on the lens, cornea and anterior chamber in phakic patients who have received consecutive intravitreal injections. 157 patients who did not have corneal pathology but were treated with 1.25mg/0.05ml intravitreal bevacizumab, 0.5mg/0.5ml ranibizumab or 2mg/0.05ml aflibercept injections due to diabetic macular edema were retrospectively analyzed in our clinic. Patients who received three consecutive monthly injections were included to the study. Corneal thickness, lens thickness and anterior chamber depth measurements which were taken before the injections, 1 month after the first injection, 1 month after the second injection, and 1 month after the third injection were used in the study. There was no statistical difference between the bevacizumab, ranibizumab, aflibercept and control group in terms of preoperative specifications such as number of patients, gender and age average. A statistically significant difference was found between the 4 anterior chamber depth measurements in the control group, Ranibizumab drug group, and Bevacizumab and Aflibercept drug groups (p<0.001, p=0.026; p=0.07, p<0.001, respectively). Anterior chamber depth of the Ranibizumab and Bevacizumab patients decreased in the first month and increased in the second and third months. However, anterior chamber depth of the Aflibercept patients increased over time. As a result of our study; we concluded that three different anti- VEGF drug molecules have an effect on the anterior camera.en_US
dc.identifier.doi10.5455/medscience.2023.01.02
dc.identifier.endpage80en_US
dc.identifier.issn2147-0634
dc.identifier.issue1en_US
dc.identifier.startpage76en_US
dc.identifier.trdizinid1176204en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2023.01.02
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1176204
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14828
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleComparison of the effects of 3 different anti-VEGF drugs on cornea thickness, lens thickness and anterior chamber depth: Case-Control Studyen_US
dc.typeArticleen_US

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