Evaluation of the Ocular Surface, Conjunctival Impression Cytology and Meibomian Gland Dropout in Patients with Familial Mediterranean Fever

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dc.authorscopusid56650731100
dc.authorscopusid55964654600
dc.authorscopusid57267454200
dc.authorscopusid57267454300
dc.authorscopusid57210984903
dc.authorscopusid14518977800
dc.contributor.authorBozkurt, E.
dc.contributor.authorMuhafiz, E.
dc.contributor.authorErat, Y. E.
dc.contributor.authorArslan, E. Ö.
dc.contributor.authorBozkurt, H. B.
dc.contributor.authorErguven, M.
dc.date.accessioned2021-12-01T18:38:48Z
dc.date.available2021-12-01T18:38:48Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractPurpose: Familial Mediterranean fever (FMF) is an idiopathic disease with chronic inflammation. We aimed to determine the changes caused by the chronic inflammatory nature of FMF on the ocular surface, meibomian glands (MG), and conjunctiva via conjunctival impression cytology (CIC). Material-method: Forty-two FMF patients with a mean age of 11.93 ± 3.92 years and 36 control patients with a mean age of 11.83 ± 3.38 years were included in the study. Ocular surface anomalies of the patients were evaluated using Schirmer II, TBUT and OSDI. MG function (meibum quality), morphology (meiboography), and CIC were evaluated. Results: Although there was a significant difference between the groups in terms of Schirmer II and TBUT, OSDI scores did not significantly differ (P = 0.022, 0.010, and 0.099 respectively), and no significant dry eye sign was observed in either group. There was significant difference between the groups in terms of the percent area of MG dropout, MG density, meiboscore (P = 0.020, 0.023, and 0.031 respectively), but no significant difference was observed in relation to MG quality (P = 0.650). Although conjunctival impression cytology was of a higher grade in the patients with FMF according to Nelson's classification, no significant difference was observed between the groups (P = 0.109). Conclusion: Although there was a decrease in the number of MGs in FMF patients, no significant deterioration was observed in conjunctival cytology. In these patients, tear film stability may deteriorate in particular. Clinicians should be aware of the possibility of ocular surface disease secondary to MG dropout in patients with FMF. © 2021 Elsevier Masson SASen_US
dc.description.sponsorshipWe thank Hatice Beseren for her interest, support and contribution to histological studies.en_US
dc.identifier.doi10.1016/j.jfo.2021.05.007
dc.identifier.endpage1325en_US
dc.identifier.issn01815512
dc.identifier.issue9en_US
dc.identifier.pmid34561094en_US
dc.identifier.scopus2-s2.0-85115394398en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1319en_US
dc.identifier.urihttps://doi.org/10.1016/j.jfo.2021.05.007
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9844
dc.identifier.volume44en_US
dc.identifier.wosWOS:001215392000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Masson s.r.l.en_US
dc.relation.ispartofJournal Francais d'Ophtalmologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConjunctival impression cytologyen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectMeibomian gland dropouten_US
dc.subjectOcular surfaceen_US
dc.titleEvaluation of the Ocular Surface, Conjunctival Impression Cytology and Meibomian Gland Dropout in Patients with Familial Mediterranean Feveren_US
dc.typeArticleen_US

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