Association of serum albumin levels with traditional risk factors and insulin resistance among Turkish adults

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dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorOnat, Altan
dc.contributor.authorHergenç, Gülay
dc.contributor.authorEsen, Ali Metin
dc.contributor.authorCan, Günay
dc.contributor.authorUyarel, Hüseyin
dc.date.accessioned2020-04-30T13:32:08Z
dc.date.available2020-04-30T13:32:08Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: We investigated serum albumin levels and their association with insulin resistance (IR), metabolic syndrome (MS), coronary heart disease (CHD), and traditional risk factors among Turkish adults. Study design: Serum albumin levels were measured colorimetrically in 1052 subjects representing the population of Western Turkey (Marmara and Central Anatolian regions), and were studied cross-sectionally. Metabolic syndrome was identified by modified criteria of the Adult Treatment Panel III. Results: The median age was 53 years. Metabolic syndrome was identified in 44.7% of males and in 49.4% of females. The mean serum albumin level was 4.39±0.38 mg/dl in males and 4.34±0.33 mg/dl in females (p=0.01). In univariate analyses, serum albumin concentrations showed positive correlations with apolipoprotein B, HDL-cholesterol, and total bilirubin in both genders, a positive correlation with systolic blood pressure in females, and an inverse correlation with log CRP in males. In a linear regression analysis with 11 variables for serum albumin levels, age showed an inverse, and total cholesterol showed a positive independent effect in both genders. While smoking significantly affected serum albumin levels in females, this relationship was only of near significance in males. Other independent variables were serum creatinine in females (positive), and diastolic blood pressure (positive) and log HOMA (inverse) in males. In age- and sex-adjusted analyses, serum albumin showed no correlations with MS and CHD. Conclusion: Independent of renal dysfunction, insulin resistance may contribute to low serum albumin levels in Turkish men and, in this context, may be playing a mediating role for oxidative stress and subclinical chronic inflammation.en_US
dc.identifier.endpage20en_US
dc.identifier.issn1016-5169
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/109
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary disease; Insulin resistance; Metabolic syndrome X; Risk factors; Serum albuminen_US
dc.titleAssociation of serum albumin levels with traditional risk factors and insulin resistance among Turkish adultsen_US
dc.title.alternativeTürk yetişkinlerinde serum albümin düzeylerinin geleneksel risk faktörleri ve insülin direnci ile ilişkisien_US
dc.typeArticleen_US

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