Yeni heteroaromatik tiyosemikarbazon bileşiklerinin sentezi
Küçük Resim Yok
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Heteroaromatik bileşikler, yapılarında karbon atomlarının yanı sıra azot, kükürt ve oksijen gibi heteroatomlar içeren halkalı organik bileşiklerdir. Tiyosemikarbazonlar, tiyosemikarbazit bileşikleri ile aldehit veya ketonların kondenzasyonundan elde edilen Schiff bazları sınıfındandır. Konjuge azot, kükürt iskelet sistemleri ve imin grupları içermeleri sebebiyle heterohalkalı tiyosemikarbazon bileşikleri özellikle biyolojik ve farmakolojik öneme sahip bileşiklerdir. Bu tez çalışması kapsamında, potansiyel antimikrobiyal ajanlar olarak 6 (altı) yeni heteroaromatik tiyosemikarbazon bileşiği sentezlenmiştir. Yeni heteroaromatik tiyosemikarbazon bileşikleri, template metot ile 4-amino-6-kloropirimidin-5-karboksaldehit ile tiyosemikarbazit ve benzaldehit türevlerinin (4-feniltiyosemikarbazit, tiyosemikarbazit, 4-etil-3-tiyosemikarbazit 2-imidazolkarboksaldehit, 2-piridinkarboksaldehit) kondenzasyon reaksiyonu sonucu elde edilmişlerdir. Bazı sptektroskopik teknikler (element analizi, FT-IR, 1H-NMR, 13C-NMR, SEM-EDS) kullanılarak sentezlenen yeni heteroaromatik tiyosemikarbazonların yapıları aydınlatılmıştır.
Heteroaromatic compounds are cyclic organic compounds that contain heteroatoms such as nitrogen, sulfur, and oxygen in addition to carbon atoms in their structures. Thiosemicarbazones belong to the class of Schiff bases obtained by the condensation of thiosemicarbazides with aldehydes or ketones. Due to the presence of conjugated nitrogen, sulfur skeleton systems, and imine groups, heterocyclic thiosemicarbazone compounds are particularly significant in terms of their biological and pharmacological properties. In this thesis, six new heteroaromatic thiosemicarbazone compounds have been synthesized as potential antimicrobial agents. The new heteroaromatic thiosemicarbazones were obtained by the condensation reaction of 4-amino-6-chloropyrimidine-5-carbaldehyde with thiosemicarbazide and benzaldehyde derivatives (4-phenylthiosemicarbazide, thiosemicarbazide, 4-ethyl-3-thiosemicarbazide, 2-imidazolecarbaldehyde, 2-pyridinecarbaldehyde) using the template method. The structures of the synthesized new heteroaromatic thiosemicarbazones were elucidated using several spectroscopic techniques (elemental analysis, FT-IR, 1H-NMR, 13C-NMR, SEM-EDS).
Heteroaromatic compounds are cyclic organic compounds that contain heteroatoms such as nitrogen, sulfur, and oxygen in addition to carbon atoms in their structures. Thiosemicarbazones belong to the class of Schiff bases obtained by the condensation of thiosemicarbazides with aldehydes or ketones. Due to the presence of conjugated nitrogen, sulfur skeleton systems, and imine groups, heterocyclic thiosemicarbazone compounds are particularly significant in terms of their biological and pharmacological properties. In this thesis, six new heteroaromatic thiosemicarbazone compounds have been synthesized as potential antimicrobial agents. The new heteroaromatic thiosemicarbazones were obtained by the condensation reaction of 4-amino-6-chloropyrimidine-5-carbaldehyde with thiosemicarbazide and benzaldehyde derivatives (4-phenylthiosemicarbazide, thiosemicarbazide, 4-ethyl-3-thiosemicarbazide, 2-imidazolecarbaldehyde, 2-pyridinecarbaldehyde) using the template method. The structures of the synthesized new heteroaromatic thiosemicarbazones were elucidated using several spectroscopic techniques (elemental analysis, FT-IR, 1H-NMR, 13C-NMR, SEM-EDS).
Açıklama
Anahtar Kelimeler
Kimya, Chemistry
