The dose-dependent cardiovascular effects of intravenous grayanotoxin-III in rats

Basit Öğe Kaydı
dc.contributor.authorYılmaz, İsmail
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorTürker, Yasin
dc.date.accessioned2020-04-30T23:32:47Z
dc.date.available2020-04-30T23:32:47Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYaykasli, Kursat/0000-0001-7550-6370en_US
dc.descriptionWOS: 000418200900007en_US
dc.description.abstractObjective: The mad honey poisonings are commonly seen in our country. The source of the toxin in mad honey is plants of Rhododendron species. Grayanotoxin-III type toxin is commonly found in these plants. Clinical effects of this toxin are bradycardia, atrioventricular block, asystole, hypotension and symptoms such as salivation. In this study; different doses of grayanotoxin-III were intravenously administered to rats (i.v) and the effect of grayanotoxin on cardiovascular system was evaluated. Methods: This study was performed on 42 Wistar albino rats and the animals were divided into six groups. Control, Group 1 (5 mu g/kg), Group 2 (10 mu g/kg), Group 3 (20 mu g/kg), Group 4 (50 mu g/kg) and Group 5 (100 mu g/kg) groups were formed. Baseline values for electrocardiography (ECG), arterial blood pressure and respiratory rate were obtained and recorded for 60 minutes after administration of i.v. grayanotoxin-III. Results: Group1 (5 mu g/kg) was not significantly changed in all time periods. In 10 and 20 mu g/kg groups, respiratory rates, peak heart rates decreased significantly and drop in arterial blood pressures was observed after 2nd and 5th minutes. While 25 minutes after administration of i.v. grayanotoxin-III all parameters returned to baseline values again. In 50 and 100 mu g/kg grayanotoxin-III groups all parameters fell sharply from 2 minutes on, and rats died within 5-10 minutes. Conclusion: In conclusion, it was found that the lethal dose of grayanotoxin-III for rats is 50 mu g/kg. In addition the death was developed due to cardiac arrest. In case of the lower level of 5 mu g/kg grayanotoxin-III, any toxic effect was not seen. The effects of toxin apparently lasted nearly 25 minutes.en_US
dc.identifier.doi10.5222/buchd.2017.121en_US
dc.identifier.endpage128en_US
dc.identifier.issn2146-2372
dc.identifier.issn1309-9566
dc.identifier.issue2en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.5222/buchd.2017.121
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4817
dc.identifier.volume7en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherDr Behcet Uz Cocuk Hastaliklari Ve Cerrahisien_US
dc.relation.ispartofIzmir Dr Behcet Uz Cocuk Hastanesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrayanotoxin-IIIen_US
dc.subjectmad honeyen_US
dc.subjectcardiovascular effectsen_US
dc.titleThe dose-dependent cardiovascular effects of intravenous grayanotoxin-III in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu