Prevalence of High-Risk Human Papillomavirus Types and Their Association with Cervical Squamous Cell Carcinoma, and High- and Low-Grade Squamous Intraepithelial Lesions in Turkish Women

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dc.authoridErkinüresin, Taşkın/0000-0003-1725-6590en_US
dc.authorwosidErkinüresin, Taşkın/AAV-4560-2021en_US
dc.contributor.authorErkinueresin, Taskin
dc.contributor.authorKartal, Esra
dc.contributor.authorUstunyurt, Emin
dc.contributor.authorDemirci, Hakan
dc.contributor.authorKilitci, Asuman
dc.contributor.authorOnal, Binnur
dc.date.accessioned2024-08-23T16:07:20Z
dc.date.available2024-08-23T16:07:20Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: This study aimed to investigate human papillomavirus (HPV) type prevalence in our region and the relationship between uterine cervical HPV types and squamous cell carcinoma (SCC)/intraepithelial lesions.Methods: HPV test results were obtained from patient file archives of the Gynecology and Obstetrics Clinic. Pathology report results were obtained from the digital records of the Pathology Laboratory and the patient file archives of the Gynecology and Obstetrics Clinic in 2018.Results: The most frequently detected was HPV16 (29.2%), followed by HPV51 (13.1%), HPV56 (11%), HPV31 (9.2%), HPV52 (8.4%), and HPV68 (8.2%). HPV16 was positive in 50% of patients diagnosed with SCC, 54.9% of patients with HSIL, 27% of patients with LSIL, and 25% of cases diagnosed as benign (P<0.001). HPV18 was positive in 25% of patients diagnosed with SCC, 11% of patients with HSIL, 4.7% of patients with LSIL, and 5.2% of cases diagnosed as benign (P=0.019).Conclusion: The most frequent hrHPV genotype was HPV16, followed by HPV51, HPV 56, and HPV 31. There is an increase in the frequency of HPV51 and HPV56. HPV51, not included in HPV vaccines and is the second most frequent, should be included in these vaccines. In addition, although the frequency of HPV18 has decreased, HSIL and SCC generation is still high together with HPV16.en_US
dc.identifier.endpage621en_US
dc.identifier.issn2251-6085
dc.identifier.issn2251-6093
dc.identifier.issue3en_US
dc.identifier.startpage612en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14609
dc.identifier.volume52en_US
dc.identifier.wosWOS:000957156100016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIranian Scientific Society Medical Entomologyen_US
dc.relation.ispartofIranian Journal of Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCervical carcinomaen_US
dc.subjectCytologyen_US
dc.subjectEpithelial abnormalityen_US
dc.subjectHigh-risk human papillomavirusen_US
dc.subjectType prevalenceen_US
dc.subjectHpv Genotype Distributionen_US
dc.subjectCytologyen_US
dc.subjectInfectionsen_US
dc.subjectSamplesen_US
dc.subjectRegionen_US
dc.subjectCohorten_US
dc.titlePrevalence of High-Risk Human Papillomavirus Types and Their Association with Cervical Squamous Cell Carcinoma, and High- and Low-Grade Squamous Intraepithelial Lesions in Turkish Womenen_US
dc.typeArticleen_US

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