Synthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogens

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dc.contributor.authorDurmuş, Sefa
dc.contributor.authorDalmaz, Aslıhan
dc.contributor.authorDülger, Görkem
dc.contributor.authorKadıoğlu, Duygu Bircan
dc.date.accessioned2020-04-30T23:32:27Z
dc.date.available2020-04-30T23:32:27Z
dc.date.issued2017
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionWOS: 000467956600006en_US
dc.description.abstractThio-Schiff bases are becoming increasingly widespread in various branches such as the preparation of certain medicines, cosmetic products, and polymer production. In particular, the presence of antibacterial, antifungal, antiviral, antitumor and antimalarial properties of Schiff bases containing sulfur in the structure has made these compounds attractive in different disciplines. In this study, different derivatives of dimeric disulfide-Schiff bases have been synthesized. The antibacterial and antifungal activities of the synthesized these compounds were investigated in vitro against some human pathogens (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans, C. tropicalis, C. guilliermondii and C. glabrata). Test microorganisms were isolated from the patients appyling to Medical Faculty Hospital of Duzce University were used. Diffusion method was used to determine the antimicrobial activities of the compounds. standard antibacterial (Cefotaxime, Amoxicillin/clavulanicacid) and antifungal (Posaconazole) antibiotics were used as the control group and the results were compared. The result indicated that antimicrobial activity of Disulphide-Schiff Base Derivatives exhibited less activity against bacteria as compared to AMC30 (Amoxicillin/clavulanicacid), but highly effective against bacteria as compared to CTX30 (Cefotaxime). In addition, the compounds exhibited less activity against yeast.en_US
dc.description.sponsorshipDuzce University Scientific Research Fund (BAP) [2014-05-03-259, 2015-05-03-354]en_US
dc.description.sponsorshipThis work is supported by the Duzce University Scientific Research Fund (BAP) (Project Number: 2014-05-03-259 and 2015-05-03-354).en_US
dc.identifier.doi10.24190/ISSN2564-615X/2017/03.06en_US
dc.identifier.endpage234en_US
dc.identifier.issn2564-615X
dc.identifier.issue3en_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.24190/ISSN2564-615X/2017/03.06
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4722
dc.identifier.volume1en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofEurobiotech Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSynthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogensen_US
dc.typeArticleen_US

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