Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania

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dc.contributor.authorKütük, Meryem Özlem
dc.contributor.authorTufan, Ali Evren
dc.contributor.authorKılıçaslan, Fethiye
dc.contributor.authorMutluer, Tuba
dc.contributor.authorGökçen, Cem
dc.contributor.authorKaradağ, Mehmet
dc.contributor.authorKütük, Özgür
dc.date.accessioned2020-04-30T13:32:54Z
dc.date.available2020-04-30T13:32:54Z
dc.date.issued2020
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractImmune dysregulation may be important in the etiology of obsessive-compulsive and related disordersandbody-focusedrepetitivebehaviors, such as Trichotillomania (TTM). The role of inflammation and inflammatory markers in TTM has received relatively little attention. This study was aimed to determine the expression levels of inflammatory markers (i.e. IL-1?, IL-1?, IL-4, IL-6, IL-17, TNF-? and TGF-?) in peripheral blood mononuclear cells of children with TTM and healthy controls and to evaluate their association with clinical variables. Seventy-seven patients with TTM and 107 healthy controls were enrolled in the study. Peripheral blood was collected in standardized conditions. The mean age of patients and controls did not differ significantly (10.8 ± 4.4 and 12.0 ± 3.2 years; respectively). The majority of patients with TTM and controls were females (n = 55, 71.4 % and n = 55, 51.4 %; respectively); with a greater preponderance of females among TTM. Patients with TTM had significantly elevated expression levels of TNF-?, IL-6 and IL-17 compared to controls. However, the expression level of IL-4 was significantly reduced in TTM patients compared to controls. Accordingly, we found a pro-inflammatory state in TTM and those findings may suggest novel treatment options for TTM and further, cross-disciplinary studies focusing on neuro- inflammation in TTM conducted on larger samples are needed. © 2020 Elsevier GmbHen_US
dc.description.sponsorshipBilim Akademisien_US
dc.description.sponsorshipOzgur Kutuk acknowledges support from the Science Academy BAGEP program.en_US
dc.identifier.doi10.1016/j.imbio.2020.151913en_US
dc.identifier.issn0171-2985
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.imbio.2020.151913
dc.identifier.urihttps://hdl.handle.net/20.500.12684/475
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier GmbHen_US
dc.relation.ispartofImmunobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokines; Immune system; Inflammation; Obsessive- compulsive and related disorders; Trichotillomaniaen_US
dc.titleNovel inflammatory targets for immunotherapies in pediatric patients with trichotillomaniaen_US
dc.typeArticleen_US

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