Effect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin induced epilepsy

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dc.authoridKILIÇ, Ümit/0000-0001-9917-0648en_US
dc.authorwosidKILIÇ, Ümit/KEJ-4241-2024en_US
dc.contributor.authorUmit, Kilic
dc.contributor.authorHayriye, Soytuerk
dc.date.accessioned2024-08-23T16:03:23Z
dc.date.available2024-08-23T16:03:23Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractOpening or closing of K-ATP channels affects some signaling pathways in the brain. These signaling pathways are thought to be associated with epilepsy. Here, we investigated the effect of K-ATP channel opener and blocker on the AKT mTOR mRNA expressions in the hippocampus and cortex regions in the penicillin model of epilepsy in rats. Four groups were created viz. Control (C), Epilepsy (E), Epilepsy-Opener (E-O) and Epilepsy-Blocker (E-B). Epileptic focus was created by administering penicillin into the brain, and the seizure-related AKT, mTOR mRNA levels were determined by qPCR on days 1(st), 4(th), and 8(th) after the seizure. The AKT mRNA expression levels in the hippocampus were statistically significant (P <0.05) in the E 1(st) day group. mTOR mRNA expression levels were observed to be significantly higher in the E 1(st) day and 8(th) day groups than in control and all opener groups. (P <0.05). mTOR mRNA expression levels were significantly higher in the E-B 1(st) day and 8(th) day group compared to the control and opener groups (P <0.05). AKT mRNA expression levels in the cortex were found to be statistically significantly higher in the E 1(st) day group than in the other groups. mTOR mRNA expression was significantly higher in the E 4(th) day group than in the control group. The results suggest that activation of the AKT/mTOR signaling pathway is effective in the development of epilepsy and that the effect of KATP channels on epilepsy may be via the AKT/mTOR signaling pathway.en_US
dc.description.sponsorshipAbant Izzet Baysal University Research Foundation [2019.10.01.1408]en_US
dc.description.sponsorshipThis study was financed by the Abant Izzet Baysal University Research Foundation (BAP-grant number: 2019.10.01.1408) .en_US
dc.identifier.doi10.56042/ijeb.v61i09.1547
dc.identifier.endpage686en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue9en_US
dc.identifier.startpage681en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v61i09.1547
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13710
dc.identifier.volume61en_US
dc.identifier.wosWOS:001066512100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntidiabeticen_US
dc.subjectCellular stressen_US
dc.subjectEpileptogenesisen_US
dc.subjectGlibenclamideen_US
dc.subjectPinacidilen_US
dc.subjectMammalian Targeten_US
dc.subjectTuberous Sclerosisen_US
dc.subjectSignaling Pathwayen_US
dc.subjectMouse Modelen_US
dc.subjectRapamycin Mtoren_US
dc.subjectInhibitionen_US
dc.subjectReceptoren_US
dc.subjectChannelsen_US
dc.subjectDeathen_US
dc.subjectEpileptogenesisen_US
dc.titleEffect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin induced epilepsyen_US
dc.typeArticleen_US

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