Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

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dc.authorscopusid57812293200
dc.authorscopusid7006702494
dc.authorscopusid28367543600
dc.authorscopusid57972091200
dc.authorscopusid57188813441
dc.contributor.authorŞahin Yıldız, Yasemin
dc.contributor.authorDemir, Şerif
dc.contributor.authorBeyazçiçek, E.
dc.contributor.authorGök, A.
dc.contributor.authorBeyazçiçek, Özge
dc.date.accessioned2023-07-26T11:53:48Z
dc.date.available2023-07-26T11:53:48Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractEpilepsy is a neurological disease characterized by sudden and synchronized seizures caused by abnormal and excessive electrical discharges in brain neurons. The purpose of this study was to electrophysiologically examine the effects of acute administration of irisin, which is thought to be neuroprotective and increase cell proliferation, at different doses (10 and 100 nM) on the penicillin-induced experimental epilepsy in rats. Forty-nine adult male Wistar rats were used in the study. The rats were divided into 7 groups: sham, control group (penicillin), irisin group, the pre- and during-seizure groups of 10 nM and 100 nM irisin. All the substances except penicillin were administered intraperitoneally. The rats were anesthetized using urethane. The bone tissue on the left cerebral cortex was removed and the electrodes were placed in the somatomotor cortex. Thirty minutes before penicillin administration, irisin was administered to the pre-seizure penicillin group at doses of 10 nM and 100 nM. Then, penicillin (500 IU/2 µl) was injected intracortically, and ECoG recording was continued for 120 minutes. On the other hand, 10 nM and 100 nM of irisin were administered to the during-seizure penicillin group after penicillin was injected intracortically and the seizure occurred, and ECoG recording was continued for 120 minutes. The ECoG recordings were analyzed using the PowerLab Chart v.8 software. In conclusion, it was found that irisin prolonged the latency of initial epileptic activity and decreased the number and amplitude of spike-waves in the penicillin-induced experimental epilepsy model. These results suggest that irisin might have an antiepileptic potential. © 2022 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.description.sponsorshipEge University Research Foundationen_US
dc.description.sponsorshipThis study was financed by the Düzce University Research Foundation (BAP-grand number:2020.04.01.1074).en_US
dc.identifier.doi10.52142/omujecm.39.4.26
dc.identifier.endpage1067en_US
dc.identifier.issn1309-4483
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85142301629en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1061en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.39.4.26
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12607
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDemir, Şerif
dc.institutionauthorBeyazçiçek, E.
dc.institutionauthorGök, A.
dc.institutionauthorBeyazçiçek, Özge
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectelectrocorticographyen_US
dc.subjectepilepsyen_US
dc.subjectepileptiform activityen_US
dc.subjectirisinen_US
dc.subjectraten_US
dc.subjectirisinen_US
dc.subjectpenicillin derivativeen_US
dc.subjectpenicillin Gen_US
dc.subjecturethanen_US
dc.subjectadulten_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectArticleen_US
dc.subjectbone structureen_US
dc.subjectbone tissueen_US
dc.subjectbrain cortexen_US
dc.subjectcell proliferationen_US
dc.subjectcontrolled studyen_US
dc.subjectelectrocorticographyen_US
dc.subjectelectrophysiological proceduresen_US
dc.subjectepileptic dischargeen_US
dc.subjectexperimental epilepsyen_US
dc.subjectintraperitoneal drug administrationen_US
dc.subjectlatent perioden_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectprotein functionen_US
dc.subjectraten_US
dc.subjectreference electrodeen_US
dc.subjectroom temperatureen_US
dc.subjectspike waveen_US
dc.subjectsurgical techniqueen_US
dc.subjectWistar raten_US
dc.titleEffect of irisin on the epilepsy induced by penicillin G: An electrophysiological studyen_US
dc.typeArticleen_US

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