Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors

Basit Öğe Kaydı
dc.authorid
dc.contributor.authorDemirci, Tuna
dc.contributor.authorÖzdemir, Oğuzhan
dc.contributor.authorKaya, Mustafa Oğuzhan
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2021-12-01T18:23:04Z
dc.date.available2021-12-01T18:23:04Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractDihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesizedand their effects on carbonic anhydrase II (hCAII) have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives inbasic condition and then hydrolyzed with hydrochloric acid. The targeted compounds were synthesized from amino sulfanilamide, dihydro [2,3D] pyridine compounds, and triethylorthoformate. 1H NMR, 13C NMR, FT-IR and elemental analysis were used for the structural analysisof the compounds. The half maximal inhibitory concentration (IC50) values of the compoundswere determined to be between 27.03 and 104.39 ?M for hCA II and 19.85-76.64 ?M for Ki.en_US
dc.identifier.doi10.16984/saufenbilder.688414
dc.identifier.endpage211en_US
dc.identifier.issn1301-4048
dc.identifier.issn2147-835X
dc.identifier.issue1en_US
dc.identifier.startpage200en_US
dc.identifier.urihttps://doi.org/10.16984/saufenbilder.688414
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRJd01qWTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9630
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofSakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleSynthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitorsen_US
dc.typeArticleen_US

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