Antibacterial, Phytochemical and Toxicological Activities of Garcinia kola Extracts against Multidrug Resistant Clinical Bacteria

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dc.contributor.authorOyetunji, Kolawole
dc.contributor.authorNwadike, Blessing
dc.date.accessioned2024-12-28T20:24:15Z
dc.date.available2024-12-28T20:24:15Z
dc.date.issued2024
dc.description.abstractObjective: The rise in multiple antibiotic resistant microorganisms has led to a decline in the efficacy of many antibiotics, prompting the investigation of alternative solutions such as medicinal plants. To tackle this concerning issue, this study was undertaken to evaluate the phytochemical composition, antibacterial activity, and toxicological characteristics of Garcinia kola extracts against multidrug-resistant bacteria commonly found in clinical settings.Material-Method: The cold maceration technique was employed to extract the root and leaf of Garcinia kola using water and methanol. The extracts were then subjected to phytochemical screening. To evaluate the extracts' potential to inhibit bacterial growth, five multidrug-resistant isolates were utilized in this study. Agar well assay was used to determine the zones of inhibition. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined using the broth macro dilution technique. Additionally, Brine shrimp lethality assay was conducted to determine the lethal concentration (LC50) of the extracts. The extracts were also combined for synergism.Results: The investigation found that the root extract in methanol had the highest yield at 25.58%. All four extracts contained ten out of the fourteen tested phytochemicals. The methanol leaf and root extracts exhibited the highest and lowest inhibition zones of 20mm and 9mm against Staphylococcus aureus, respectively. The MIC values ranged from 250 to 600 mg/ml, indicating broad-spectrum antibacterial activity. The cytotoxicity test showed a range of 33.03 to 126.3µg/mL for the aqueous and methanol extracts.Conclusion: Although Garcinia kola shows potential as a source of antibacterial compounds, caution should be exercised due to its toxic effects.
dc.identifier.dergiparkDergiPark: 1407843
dc.identifier.doi10.53811/ijtcmr.1407843
dc.identifier.endpage38
dc.identifier.issn2717-7491
dc.identifier.issue1
dc.identifier.startpage28
dc.identifier.urihttps://doi.org/10.53811/ijtcmr.1407843
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/3612178
dc.identifier.urihttps://dergipark.org.tr/tr/pub/ijtcmr/issue/84321/1407843
dc.identifier.urihttps://hdl.handle.net/20.500.12684/17156
dc.identifier.volume5
dc.language.isoen
dc.publisherDüzce Üniversitesi
dc.relation.ispartofInternational Journal of Traditional and Complementary Medicine Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241228
dc.subjectGarcinia kola
dc.subjectPhytochemicals
dc.subjectMinimum Inhibitory Concentration [MIC]
dc.subjectInhibition zones
dc.subjectCytotoxicity.
dc.subjectTraditional, Complementary and Integrative Medicine (Other)
dc.titleAntibacterial, Phytochemical and Toxicological Activities of Garcinia kola Extracts against Multidrug Resistant Clinical Bacteria
dc.typeArticle

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International Journal of Traditional and Complementary Medicine Research