Assessment of physical function, quality of life, and medication adherence in elderly patients with rheumatic diseases

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dc.authoridSultanoğlu, Tuba Erdem/0000-0003-0021-5952
dc.authorwosidSultanoğlu, Tuba Erdem/AAB-1647-2021
dc.contributor.authorErdem Sultanoğlu, Tuba
dc.contributor.authorAtaoğlu, Safinaz
dc.contributor.authorAvşar, Burcu
dc.contributor.authorMerkur, Ömer Faruk
dc.date.accessioned2023-07-26T11:54:31Z
dc.date.available2023-07-26T11:54:31Z
dc.date.issued2021
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalıen_US
dc.description.abstractBackground The proportion of older people in the total population has increased in Turkey as well as worldwide. As life expectancy rises, the increasing prevalence of rheumatic diseases poses major problems in the elderly. Comorbid diseases and the aging-induced changes in the endogenous immune response and the pharmacokinetic properties of therapeutic agents may complicate the decision to use a particular drug and result in a different clinical picture and treatment response. We, therefore, aimed to investigate the characteristics of chronic inflammatory diseases, their impact on physical function and quality of life, the prevalence of comorbid diseases that may complicate treatment planning, and treatment adherence in patients aged 65 years or older. Results One hundred seventy-four patients were included and divided into two age groups: 18-64 years (group 1, n = 85) and 65 years or older (group 2, n = 89). The mean age of all recruited patients was 57.55 +/- 16.98 years. Of 174, 99 (56.9%) were female and 75 (43.1%) were male. The mean duration of rheumatic disease was 7 +/- 4.8 years and age at onset was 51.46 +/- 14.78 years. Gender distribution differed significantly by age group (P = 0.024). The percentage of females in group 1 was 48.2% and 65.2% in group 2. The occupational status also differed significantly by age group (P < 0.001). 48.2% of group 1 were employed and 57.3% of group 2 were housewives. Marital status varied significantly by age (P < 0.001). The percentage of married was 74.1% in group 1 and the percentage of separated/divorced/widowed in group 2 was 28.1%. There was no difference between groups 1 and 2 in terms of place of residence (P = 0.459). The prevalence of comorbid diseases and the rate of use of medications for comorbid diseases (non-rheumatic treatments) were higher in elderly patients. The rate of use of disease-modifying anti-rheumatic drugs (DMARDs) was 30.3% and biological agents 61.8% in the elderly group (>= 65 years) (group 2) (P < 0.001). There were positive correlations between, Health Assessment Questionnaire (HAQ), Bath Ankylosing Spondylitis Functional Index (BASFI) and Nottingham Health Profile (NHP) domains in both groups. There was also a significant negative correlation between Medication Adherence Rating Scale (MARS) and all dimensions. Conclusions Elderly and younger patients with rheumatic diseases have different demographic and clinical characteristics. Physical function and quality of life are more affected by rheumatic diseases and treatment adherence is poorer in the elderly. Our study found a positive correlation between physical function and quality of life in both age groups. The treatment adherence rating scale showed a negative correlation with physical function and quality of life scores, with individuals with poor treatment adherence having worse physical function and quality of life.en_US
dc.identifier.doi10.1186/s43166-021-00091-0
dc.identifier.issn1110-161X
dc.identifier.issn2090-3235
dc.identifier.issue1en_US
dc.identifier.urihttps://doi.org/10.1186/s43166-021-00091-0
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12853
dc.identifier.volume48en_US
dc.identifier.wosWOS:000798303300036en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorErdem Sultanoğlu, Tuba
dc.institutionauthorAtaoğlu, Safinaz
dc.institutionauthorAvşar, Burcu
dc.institutionauthorMerkur, Ömer Faruk
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEgyptian Rheumatology and Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectRheumatic Diseases; Geriatrics; Physical Function; Quality Of Life; Treatment Adherenceen_US
dc.subjectClassification Criteria; Ankylosing-Spondylitis; Rheumatology/European League; American-College; Turkish Version; Arthritis; Onset; Risk; Burden; Cohorten_US
dc.titleAssessment of physical function, quality of life, and medication adherence in elderly patients with rheumatic diseasesen_US
dc.typeArticleen_US

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