Management of Thyrotoxicosis in Children and Adolescents: A Turkish Multi-center Experience

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dc.authorid
dc.contributor.authorEsen, İhsan
dc.contributor.authorBayramoğlu, Elvan
dc.contributor.authorYıldız, Melek
dc.contributor.authorAydın, Murat
dc.contributor.authorÖzturhan, Esin
dc.contributor.authorAycan, Zehra
dc.contributor.authorSağsak, Elif
dc.date.accessioned2021-12-01T18:23:51Z
dc.date.available2021-12-01T18:23:51Z
dc.date.issued2019
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: To determine the demographic and biochemical features of childhood and juvenile thyrotoxicosis and treatment outcome.Methods: We reviewed the records of children from 22 centers in Turkey who were diagnosed with thyrotoxicosis between 2007 to 2017.Results: A total of 503 children had been diagnosed with thyrotoxicosis at the centers during the study period. Of these, 375 (74.6%)had been diagnosed with Graves’ disease (GD), 75 (14.9%) with hashitoxicosis and 53 (10.5%) with other less common causes ofthyrotoxicosis. The most common presenting features in children with GD or hashitoxicosis were tachycardia and/or palpitations, weightloss and excessive sweating. The cumulative remission rate was 17.6% in 370 patients with GD who had received anti-thyroid drugs(ATDs) for initial treatment. The median (range) treatment period was 22.8 (0.3-127) months. No variables predictive of achievingremission were identified. Twenty-seven received second-line treatment because of poor disease control and/or adverse events associatedwith ATDs. Total thyroidectomy was performed in 17 patients with no recurrence of thyrotoxicosis and all became hypothyroid. Tenpatients received radioiodine and six became hypothyroid, one remained hyperthyroid and restarted ATDs and one patient achievedremission. Two patients were lost to follow up.Conclusion: This study has demonstrated that using ATDs is the generally accepted first-line approach and there seems to be lowremission rate with ATDs in pediatric GD patients in Turkey.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2018.2018.0210
dc.identifier.endpage172en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue2en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2018.2018.0210
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpNME16VXhNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9786
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndokrinoloji ve Metabolizmaen_US
dc.subjectPediatrien_US
dc.titleManagement of Thyrotoxicosis in Children and Adolescents: A Turkish Multi-center Experienceen_US
dc.typeArticleen_US

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