Kısa, orta, uzun zincirli yağ asitlerinin osteokalsin, leptin ve insülin düzeylerine etkilerinin araştırılması
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Dosyalar
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Pankreas beta hücrelerinden salınan insülin, kemik dokuda hem aktif hem de inaktif osteokalsin ve yağ dokusunda salınan leptin ile ilgili çok sayıda çalışma mevcuttur. Fakat kombine kısa, orta ve uzun yağ asitlerinin osteokalsin, leptin ve insülinin serum/doku konsantrasyonuna etkilerine dair veriler azdır. Bütürik asit, kaprilik asit ve oleik asidin kombine kullanımının osteokalsin, leptin ve insülin salgılanması üzerindeki etkilerini araştırmayı amaçlamaktadır. Çalışmada 49 adet erkek wistar cinsi sıçan kullanıldı. Sıçanlar rastgele kontrol grubu, bütirik asit grubu, kaprilik asit grubu, oleik asit grubu, bütirik asit+kaprilik asit grubu, bütirik asit+oleik asit grubu ve kaprilik asit+oleik asit grubu olmak üzere 7 gruba ayrıldı. 21 gün süresince oral olarak yağ asidi uygulandı. Çalışma sonunda sıçanlardan alınan serum örneklerinden osteokalsin, insülin ve leptin düzeyleri ELİSA yöntemi ile belirlendi. Sadece bütürik asit uygulanan grupta osteokalsin ve leptin seviyesi yüksek bulunurken, kombine kaprilik asit+oleik asit uygulanan grupta insülün seviyesi daha yüksek bulundu. Kaprilik asit uygulanan grubun kan glukoz seviyesi diğer gruplara göre daha yüksek olarak saptandı. Sonuç olarak, osteokalsin, leptin ve insülin arasındaki ilişki oldukça karmaşıktır. Farklı çalışmalar, osteokalsinin leptin direnci üzerinde etkili olabileceğini, farklı türdeki yağ asitlerinin özellikle kısa zincirli yağ asitlerinin tüketiminin osteokalsin salınımını artırarak insülin duyarlılığına katkıda bulunabileceğini, leptin direncinin azaltılmasına yardımcı olabileceğini ve osteokalsinin insülin direncini azaltabileceğini göstermektedir.
There are many studies on insülin released from pancreatic beta cells, both active and inactive osteocalcin in bone tissue, and leptin released in adipose tissue. However, data on the effects of combined short, medium and long fatty acids on the serum/tissue concentration of hormones such as osteocalcin, leptin and insülin are scarce. This study aims to investigate the effects of combined use of butyric acid, caprylic acid and oleic acid on osteocalcin, leptin and insulin secretion. Forty-nine male Wistar rats were used in the study. The rats were randomly divided into 7 subgroups as control group, butyric acid group, caprylic acid group, oleic acid group, butyric acid+caprylic acid group, butyric acid+oleic acid group, and caprylic acid+oleic acid group. Fatty acid was administered orally for 21 days. At the end of the study, osteocalcin, insulin, and leptin levels of serum samples taken from rats were determined by the ELISA method. While osteocalcin and leptin levels were found to be high in the group administered only butyric acid, insulin levels were found to be higher in the group treated with combined caprylic acid + oleic acid. The blood glucose level of the caprylic acid group was found to be higher than the other groups. In conclusion, the relationship between osteocalcin, leptin, and insulin is quite complex. Different studies show that osteocalcin can have an effect on leptin resistance, consumption of different types of fatty acids, especially short-chain fatty acids, can contribute to insulin sensitivity by increasing the release of osteocalcin, can help reduce leptin resistance, and osteocalcin can reduce insulin resistance.
There are many studies on insülin released from pancreatic beta cells, both active and inactive osteocalcin in bone tissue, and leptin released in adipose tissue. However, data on the effects of combined short, medium and long fatty acids on the serum/tissue concentration of hormones such as osteocalcin, leptin and insülin are scarce. This study aims to investigate the effects of combined use of butyric acid, caprylic acid and oleic acid on osteocalcin, leptin and insulin secretion. Forty-nine male Wistar rats were used in the study. The rats were randomly divided into 7 subgroups as control group, butyric acid group, caprylic acid group, oleic acid group, butyric acid+caprylic acid group, butyric acid+oleic acid group, and caprylic acid+oleic acid group. Fatty acid was administered orally for 21 days. At the end of the study, osteocalcin, insulin, and leptin levels of serum samples taken from rats were determined by the ELISA method. While osteocalcin and leptin levels were found to be high in the group administered only butyric acid, insulin levels were found to be higher in the group treated with combined caprylic acid + oleic acid. The blood glucose level of the caprylic acid group was found to be higher than the other groups. In conclusion, the relationship between osteocalcin, leptin, and insulin is quite complex. Different studies show that osteocalcin can have an effect on leptin resistance, consumption of different types of fatty acids, especially short-chain fatty acids, can contribute to insulin sensitivity by increasing the release of osteocalcin, can help reduce leptin resistance, and osteocalcin can reduce insulin resistance.
Açıklama
Anahtar Kelimeler
Fizyoloji, Physiology
