Anticancer activities of coumarins and their structure–activity relationships

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dc.contributor.authorTaban, Kevser
dc.contributor.authorİlhan, Mert
dc.contributor.authorSüntar, Ipek Peşin
dc.date.accessioned2025-10-11T20:45:20Z
dc.date.available2025-10-11T20:45:20Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractCoumarins are naturally occurring compounds consisting of a 1,2-benzopyrone ring system. They exhibit a wide range of biological activities, including antimicrobial, antiinflammatory, antihypertensive, antihyperlipidemic, analgesic, anticoagulant, and anticancer. These compounds have attracted attention in cancer therapy by targeting a number of pathways. Among them, the main mechanism is based on cell cycle blockage and initiation of programmed cell death like apoptosis or autophagy. The recognition of the main structural features in coumarin is vital for the design and development of new analogs with enhanced activity and for the characterization of their mechanism of action and potential side effects. This chapter will highlight the key structure–activity relationships studies performed on coumarin derivates. Key structural features of the coumarin scaffold where substitutions can increase or decrease the anticancer activity of hit molecules will be discussed. © 2025 Elsevier B.V., All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-443-23754-6.00016-1
dc.identifier.endpage142en_US
dc.identifier.isbn9780444632944
dc.identifier.isbn9780444626158
dc.identifier.isbn9780444634306
dc.identifier.isbn9780444640574
dc.identifier.isbn9780444596031
dc.identifier.isbn9780444636034
dc.identifier.isbn9780444639325
dc.identifier.isbn9780444636027
dc.identifier.isbn9780444632814
dc.identifier.issn1572-5995
dc.identifier.scopus2-s2.0-105003745148en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage105en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-443-23754-6.00016-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21286
dc.identifier.volume85en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofStudies in Natural Products Chemistryen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250911
dc.subjectAnticanceren_US
dc.subjectCoumarinen_US
dc.subjectStructure–activity Relationshipen_US
dc.titleAnticancer activities of coumarins and their structure–activity relationshipsen_US
dc.typeBook Parten_US

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