Investigation of the cardioprotective effects of Momordica charantia in the isoproterenol-induced myocardial infarction model in rats

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dc.authorscopusid59249691100en_US
dc.authorscopusid57188813441en_US
dc.contributor.authorKaradeniz, B.
dc.contributor.authorBeyazcicek, O.
dc.date.accessioned2024-08-23T16:07:39Z
dc.date.available2024-08-23T16:07:39Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: Cardiovascular diseases are the most prevalent and primary cause of death globally, and the most deadly and dangerous of these diseases is myocardial infarction (MI), commonly known as heart attack, which develops due to insufficient coronary artery flow and causes irreversible myocardial cell damage. This study aimed to investigate the cardioprotective effects of Momordica charantia (MC), known for its antioxidant and anti-inflammatory properties, in an experimental acute MI model induced by isoprenaline (ISO) in rats. Methods: In the study, forty-nine male Wistar rats were split up into 7 groups as control (CONT), Glycerin (GLCN), isoprenaline (ISO), 500 mg/kg MC (MC500), isoprenaline+100 mg/kg MC (ISO+MC100), isoprenaline+250 mg/kg MC (ISO+MC250), isoprenaline+500 mg/kg MC (ISO+MC500). Substances were administered to the groups for 30 days. Isoprenaline (85 mg/kg) was administered by subcutaneous injection on the last two days of the study (days of the 29 and 30). Electrocardiogram (ECG) recording and collecting blood samples of the animals were performed 24 hours after the last administration of the substances under the anesthesia. Serum IL-6, Nrf2, IL-10, HO-1, TNF-?, CK-MB, cTn-I and CRP levels were determined by the ELISA method. Results: Compared to the ISO group, levels of CK-MB, HO-1, TNF-?, CRP, IL-6 and cTn-I were found statistically lower in MC-administered groups (p<0.05). In addition, MC restored ISO-induced abnormal ECG changes to normal levels. Conclusion: In conclusion, ECG findings, proinflammatory, anti-inflammatory, antioxidative and cardiac biomarkers suggest that MC may have cardioprotective properties. © 2024en_US
dc.description.sponsorshipAjou University, (2023.04.01.1394); Ajou Universityen_US
dc.identifier.doi10.1016/j.biopha.2024.117274
dc.identifier.issn0753-3322
dc.identifier.scopus2-s2.0-85200601629en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2024.117274
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14759
dc.identifier.volume178en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Masson s.r.l.en_US
dc.relation.ispartofBiomedicine and Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-inflammatoryen_US
dc.subjectAntioxidant activityen_US
dc.subjectcardiac biomarkersen_US
dc.subjectelectrocardiogramen_US
dc.subjectbiological markeren_US
dc.subjectC reactive proteinen_US
dc.subjectcreatine kinase MBen_US
dc.subjectglycerolen_US
dc.subjectheme oxygenase 1en_US
dc.subjectimmunaten_US
dc.subjectinterleukin 10en_US
dc.subjectinterleukin 6en_US
dc.subjectisoprenalineen_US
dc.subjectMomordica charantia extracten_US
dc.subjecttranscription factor Nrf2en_US
dc.subjecttroponin Ien_US
dc.subjecttumor necrosis factoren_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantiinflammatory activityen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectblood samplingen_US
dc.subjectbody weighten_US
dc.subjectcontrolled studyen_US
dc.subjectECG abnormalityen_US
dc.subjectelectrocardiogramen_US
dc.subjectenzyme blood levelen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectheart protectionen_US
dc.subjectheart weighten_US
dc.subjectisoproterenol-induced myocardial infarctionen_US
dc.subjectmaleen_US
dc.subjectMomordica charantiaen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjecttherapy effecten_US
dc.titleInvestigation of the cardioprotective effects of Momordica charantia in the isoproterenol-induced myocardial infarction model in ratsen_US
dc.typeArticleen_US

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