Exercise and metformin effect on glucose homeostasis and gastrointestinal hormone levels in rats

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dc.contributor.authorOnay, Fatma
dc.contributor.authorBeyazcicek, Ozge
dc.date.accessioned2025-10-11T20:47:36Z
dc.date.available2025-10-11T20:47:36Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThis study aimed to determine the effects of exercise and metformin on glucagon-like peptide-1 (GLP-1), glucosedependent insulinotropic polypeptide (GIP), insulin (INS), ghrelin (GHRL), and blood glucose levels. Forty-two male Wistar rats were divided into 6 groups as control (CONT), exercise only (EXE), metformin 100 mg/kg (Met100), metformin 200 mg/kg (Met200), metformin 100mg+exercise (Met100+EXE), and metformin 200mg+exercise (Met200+EXE). Metformin was administered intraperitoneally. Rats were subjected to an incremental exercise protocol. A 12-week study was conducted, including an adaptation period for exercise. At the end of the study, serum samples were obtained from the rats, and the levels of GLP-1, GIP, insulin, and ghrelin were determined using the ELISA method. The blood glucose levels of the Met200 group were lower than CONT, EXE, and combination groups. INS levels of the metformin and combination groups were lower than CONT group. GLP-1 level of EXE was higher than all groups. GIP levels of EXE and combination groups were higher than CONT and Met100 groups. The ghrelin levels of the exercise and Met200 group were higher than CONT group. As a result, it was determined that exercise and metformin had significant effects on glucose homeostasis and caused significant results on GIP, GLP-1, INS, and GHRL.en_US
dc.description.sponsorshipDuzce University Research Fund [2023.04.01.1392]en_US
dc.description.sponsorshipThis project is supported by Duzce University Research Fund Project Number: 2023.04.01.1392.en_US
dc.identifier.doi10.56042/ijeb.v63i02.10247
dc.identifier.endpage141en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue2en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v63i02.10247
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21461
dc.identifier.volume63en_US
dc.identifier.wosWOS:001428597600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectMetabolismen_US
dc.subjectGlucoseen_US
dc.subjectDiabetesen_US
dc.subjectIncretin hormonesen_US
dc.titleExercise and metformin effect on glucose homeostasis and gastrointestinal hormone levels in ratsen_US
dc.typeArticleen_US

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