A COMPARISON OF PLASMA NITRITE, NTTRATE AND ASYMMETRIC DIMETHYL ARGININE LEVELS MAJOR DEPRESSION PATIENTS BEFORE AND AFTER ESCITALOPRAM TREATMENT

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dc.contributor.authorHisarvant, Arzu
dc.contributor.authorAtaoğlu, Ahmet
dc.contributor.authorÖzçetin, Adnan
dc.contributor.authorKılıç, Osman
dc.contributor.authorÖlmez, Safiye Bahar
dc.contributor.authorKuduban, Ali Kemal
dc.date.accessioned2020-04-30T22:38:38Z
dc.date.available2020-04-30T22:38:38Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000431870500004en_US
dc.description.abstractObjective: Asymmetric dimethyl arginine (ADMA) f unction, which is an intracellular repressor of nitric oxide (NO) and NO, examined and revealed in many mental disorders. In this study, we compared the simultaneous levels of plasma nitrite (NO), nitrate (NO3) and ADMA before and after escitalopram treatment at Major Depression Disorder (MDD) patients and healthy controls. Material and Method: 40 patients with MDD according to DSM-IV-IR and 40 heathy controls was included in this study. The Montgomery-Asberg Depression Rating Scale was used to determine the severity of illness. Plasma NO2, NO3 and ADMA levels were measured in the MDD and the control groups. Results: Pretreatment plasma NO2, NO3 and ADMA levels in MDD group were significantly lower (but ADMA levels were higher) than in the control group. After the treatment NO levels of MDD group were close to control group. ADMA levels were statistically lower than the control group. Conclusion: Our study can contribute to the understanding of the role of NO and ADMA and relationship between complicated neurotransmitter systems at MDD etiopathogenesis.en_US
dc.identifier.endpage30en_US
dc.identifier.issn1305-2381
dc.identifier.issue1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2331
dc.identifier.volume14en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherNobel Ilacen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDepressive disorderen_US
dc.subjectnitraten_US
dc.subjectnitriteen_US
dc.subjectasymmetric dimetilaigininen_US
dc.subjectescitalopramen_US
dc.titleA COMPARISON OF PLASMA NITRITE, NTTRATE AND ASYMMETRIC DIMETHYL ARGININE LEVELS MAJOR DEPRESSION PATIENTS BEFORE AND AFTER ESCITALOPRAM TREATMENTen_US
dc.typeArticleen_US

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