Effect of acute and chronic ellagic acid administration on penicillin induced epileptiform activity in rats

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dc.contributor.authorBeyazcicek, Ersin
dc.contributor.authorAnkarali, Seyit
dc.contributor.authorBeyazcicek, Ozge
dc.contributor.authorAnkarali, Handan
dc.date.accessioned2025-10-11T20:47:36Z
dc.date.available2025-10-11T20:47:36Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractOne of the flavonoids found in some fruits and plants such as pomegranates, nuts, and apples is ellagic acid (EA). This compound has antidepressant, anxiolytic, antioxidant, and anti-inflammatory effects. Aim of this study was to investigate the effects of EA on experimental penicillin-induced epilepsy model electrophysiologically in rats. In this study, 70 adult male Wistar rats were divided into acute and chronic main groups. Only EA, and 10, 50 and 100 mg/kg doses of EA were the subgroups of the study. Sham and control groups were used as common groups for acute and chronic main groups. Substances were given to the acute group 30 min before the epileptiform activity started but for 21 days to the chronic group. Rats were anaesthetized with urethane. Electrodes were placed on the left somatomotor area. Electrocorticography (ECoG) recording was started and then penicillin was injected into the rats to induce epileptiform activity. 120 min more ECoG recordings were taken after penicillin was injected. In sham and only EA groups there was no epileptiform activity. Both acute and chronic groups of EA significantly increased the latency time to onset of the first spike-wave (P<0.05) and decreased the frequency and amplitude except for some time periods (P<0.05). Consequently, the administration of EA has an antiepileptic effect in penicillin-induced epilepsy in rats. Therefore it may be a potential anti-epileptogenic drug in the future.en_US
dc.identifier.doi10.56042/ijeb.v62i11.4222
dc.identifier.endpage912en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue11en_US
dc.identifier.startpage902en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v62i11.4222
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21462
dc.identifier.volume62en_US
dc.identifier.wosWOS:001376388900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAntiepilepticen_US
dc.subjectElectrocorticographyen_US
dc.subjectNeuroprotectiveen_US
dc.subjectOnset of first epileptiform activityen_US
dc.titleEffect of acute and chronic ellagic acid administration on penicillin induced epileptiform activity in ratsen_US
dc.typeArticleen_US

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