Investigation of Physiological Role of Mitochondrial KATP Channel’s on Penicillin G Induced Experimental Epilepsy Model in Rats

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dc.contributor.authorSoytürk, Hayriye
dc.contributor.authorDemir, Serif
dc.contributor.authorBozdoğan, Ömer
dc.date.accessioned2025-03-24T19:50:43Z
dc.date.available2025-03-24T19:50:43Z
dc.date.issued2021
dc.departmentDüzce Üniversitesi
dc.description.abstractEpilepsy is one of the neurological diseases that is commonly seen in the world. It is characterized by excessive activation of neurons that can not be controlled by the central nervous system. ATP dependent potassium (KATP) channel modulation is related with the epilepsy. This study is intended to research the physiological role of mitochondrial KATP channels in epilepsy in electrophysiological perspective. And bepridil has been used for this purpose. Wistar albino rats have been used. Animals have been divided into three main groups; Control, bepridil applied groups in pre-seizure, and during seizure. As a result, bepridil once applied prior to seizure in 0.1 and 1mg/kg doses increased the latency period of the seizure. Bepridil showed anticonvulsant effect at doses of 0.1 and 1 mg/kg before and during seizure groups. Closure of sarcoplasmic channels and opening of mitochondrial channels may be important to decrease the convultion occurred during epilepy.
dc.identifier.endpage29
dc.identifier.issn1308-7312
dc.identifier.issue1
dc.identifier.startpage19
dc.identifier.urihttps://hdl.handle.net/20.500.12684/20048
dc.identifier.volume16
dc.language.isoen
dc.publisherE-Journal of New World Sciences Academy
dc.relation.ispartofMedical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250324
dc.subjectEpilepsy|Electrophysiology|KATP|Bepridil|Mito KATP Channel|Epilepsy
dc.titleInvestigation of Physiological Role of Mitochondrial KATP Channel’s on Penicillin G Induced Experimental Epilepsy Model in Rats
dc.typeArticle

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