Prospective evidence for physical activity protecting Turkish adults from metabolic disorders

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dc.contributor.authorOnat, Altan
dc.contributor.authorHergenç, Gülay
dc.contributor.authorKüçükdurmaz, Zekeriya
dc.contributor.authorBulur, Serkan
dc.contributor.authorKaya, Zekeriya
dc.contributor.authorCan, Günay
dc.date.accessioned2020-04-30T13:33:10Z
dc.date.available2020-04-30T13:33:10Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: We investigated the role of physical activity levels in predicting incident coronary heart disease (CHD) and certain metabolic disorders and the possible mediation of abdominal obesity. Study design: A total of 3248 participants (1601 men, 1647 women; age ?28 years; mean age 48±12 years) who were enrolled, without a previous diagnosis of CHD, into the Turkish Adult Risk Factor Survey in 1997/98 and 2002/03 were prospectively studied over an eight-year period. Physical activity levels of the participants were categorized as active or sedentary. Metabolic syndrome (MetS) was defined with the ATP-III criteria with modification for male abdominal obesity. Diagnosis of non-fatal CHD was based on history, physical examination, and the Minnesota coding of resting electrocardiograms. The mean follow-up was 6.8 years. Results: The rates of incident hypertension, diabetes, and MetS were 39%, 8.6%, and 25.4%, respectively. After adjustment for gender, age, and waist circumference, the relative risks (RR) calculated for hypertension (RR 0.76; 95% CI 0.63; 0.91), diabetes (RR 0.66; 95% CI 0.49; 0.89), and MetS (RR 0.76; 95% CI 0.60; 0.97) were significantly lower in the physically active group. Protection offered by physical activity was not mainly mediated by waist circumference or C-reactive protein, since protection from abdominal obesity risk did not reach significance. No influence of physical activity was observed on the risks for developing atherogenic dyslipidemia, elevated LDL-cholesterol, and CHD. Exercise significantly protected men from diabetes, and women from hypertension. Overall, protection from metabolic disorders was similar in both sexes. Conclusion: Physical activity, adjusted for gender and age, protects Turkish adults from incident hypertension, diabetes, and MetS. This protection is considered to operate mainly through improvements in blood pressure, beyond the mediation of abdominal obesity and low-grade inflammation.en_US
dc.identifier.endpage474en_US
dc.identifier.issn1016-5169
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/566
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood pressure; Cohort studies; Coronary disease; Diabetes mellitus, type 2; Exercise; Hypertension; Metabolic syndrome X/epidemiology; Risk factors; Turkey/epidemiologyen_US
dc.titleProspective evidence for physical activity protecting Turkish adults from metabolic disordersen_US
dc.title.alternativeFizik aktivitenin Türk yetişkinlerini metabolik bozukluklardan korudu?una ilişkin ileriye dönük kaniten_US
dc.typeArticleen_US

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