Protective Effects of N-Acetylcysteine, Carvedilol, and Paricalcitol in a Rat Model of Peritoneal Fibrosis

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dc.contributor.authorOnec, Kursad
dc.contributor.authorEkinci, Ozgur
dc.contributor.authorPasaoglu, Ozge Tugce
dc.contributor.authorAltok, Kadriye
dc.date.accessioned2026-07-01T11:39:30Z
dc.date.available2026-07-01T11:39:30Z
dc.date.issued2026
dc.departmentDüzce Üniversitesi
dc.description.abstractAim: This study aimed to evaluate the potential protective effects of paricalcitol, N-acetylcysteine (NAC), and carvedilol in a rat model of chlorhexidine gluconate-induced peritoneal fibrosis. Material and Methods: Thirty-six female Wistar albino rats were randomized into six groups (n=6 each). Peritoneal fibrosis was induced with daily intraperitoneal chlorhexidine gluconate injections for 21 days. Treatment groups received paricalcitol, NAC, or carvedilol, alone or in combination. Serum TGF-beta 1 levels and histopathological parameters (peritoneal thickness, fibrosis, inflammation, vascularization) were assessed. Results: Serum TGF-beta 1 was significantly higher in the chlorhexidine group compared to controls (58.29 +/- 4.40 vs. 49.06 +/- 2.35 ng/mL, p<0.05). NAC significantly reduced TGF-beta 1 compared to chlorhexidine alone (46.76 +/- 4.79 ng/mL, p<0.05). Peritoneal thickness was markedly increased in the chlorhexidine group (245 +/- 27.3 & micro;m vs. 22.3 +/- 2.6 & micro;m in controls, p<0.01) but attenuated by NAC (169.8 +/- 30.8 & micro;m, p<0.01) and carvedilol (146.5 +/- 43.1 & micro;m, p<0.01). Fibrosis and inflammation scores were also reduced in NAC and carvedilol groups (all p<0.05). Paricalcitol alone showed only partial and non-significant effects. Conclusions: NAC demonstrated consistent antifibrotic and anti-inflammatory effects, while carvedilol provided moderate benefit and paricalcitol had limited efficacy. These findings suggest that antioxidant therapy, particularly NAC, may represent a potential strategy for preserving peritoneal membrane integrity, though further studies are warranted.
dc.identifier.doi10.18521/ktd.1788811
dc.identifier.endpage48
dc.identifier.issn1309-3878
dc.identifier.issue1
dc.identifier.startpage43
dc.identifier.urihttps://doi.org/10.18521/ktd.1788811
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23327
dc.identifier.volume18
dc.identifier.wosWOS:001730411100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherDuzce Univ, Fac Medicine
dc.relation.ispartofKonuralp Tip Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260623
dc.subject[Keyword Not Available]
dc.titleProtective Effects of N-Acetylcysteine, Carvedilol, and Paricalcitol in a Rat Model of Peritoneal Fibrosis
dc.typeArticle

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