Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease

Basit Öğe Kaydı
dc.authorid
dc.contributor.authorİlikay, Serap
dc.contributor.authorCoşkunpınar, Ender M.
dc.contributor.authorGömleksiz, Özlem Kurnaz
dc.contributor.authorBuğra, Zehra
dc.contributor.authorEronat, Allison P.
dc.contributor.authorÖztürk, Oğuz
dc.contributor.authorAydoğan, Hülya Yılmaz
dc.date.accessioned2021-12-01T18:22:19Z
dc.date.available2021-12-01T18:22:19Z
dc.date.issued2019
dc.department[Belirlenecek]en_US
dc.description.abstractCaveolin-1 (CAV-1) plays a crucial role in endothelial-nitric oxide synthase (eNOS) enzymatic activity. Therefore, CAV-1 and eNOSinteractions have a significant impact on endothelial dysfunction, cholesterol levels, and atherosclerosis. We investigated the critical variations in NOS3 and CAV1 genes in this case–control study to determine the relations between the coronary heart disease(CHD) risk factors. The NOS3-rs1799983, CAV-1 rs3840634, and rs3807990 variations were analyzed in 76 CHD patients and 91controls using the polymerase chain reaction. Mean serum Total-cholesterol levels were significantly higher in CHD patients withthe CAV-1 rs3807990-T allele than in patients with CC genotype (p=0.017). There was a statistically significant correlation betweenthe rs3807990-T allele and hypercholesterolemia in the CHD group (p=0.008). The multivariate analysis confirmed that the CAV-1rs3807990-T allele (p=0.011) is a risk factor for hypercholesterolemia. Moreover, the serum HDL-Cholesterol level was detectedto be higher in patients carrying both CAV1-rs3807990-T and NOS3-rs1799983-T alleles than those with the CAV-1 rs3807990-CC/NOS3-rs1799983-GG genotype subgroup (p=0.013). These results suggested that the genetic variations of CAV-1 rs3807990 andNOS3-rs1799983 may contribute to the increased hypercholesterolemia risk and thus on the development of CHD.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2019.18010
dc.identifier.endpage60en_US
dc.identifier.issn2548-0731
dc.identifier.issn2587-2087
dc.identifier.issue2en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2019.18010
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpneE9EazFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9448
dc.identifier.volume49en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleEffects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart diseaseen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
9448.pdf
Boyut:
323.7 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu