Effect of Resveratrol in Acute Hypoxic Pulmonary Vasoconstriction in Isolated Lamb Pulmonary Arteries and Veins

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dc.contributor.authorSılan, Coşkun
dc.contributor.authorKuşcuoğlu, Evren
dc.contributor.authorUzun, Özge
dc.contributor.authorBalbay, Öner
dc.date.accessioned2020-05-01T09:11:46Z
dc.date.available2020-05-01T09:11:46Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionsilan, coskun/0000-0002-8352-6571; Silan, Coskun/0000-0002-8352-6571en_US
dc.descriptionWOS: 000274088000004en_US
dc.description.abstractResveratrol (RSV) is a natural phytoalexin with many biological effects, including antioxidant, anti-platelet, anti-atherogenic, anti-inflamatory, estrogenic properties, immunomodulation and chemoprevention. In the cardiovascular system, it has been shown to cause relaxation of vascular smooth muscle, and reports indicate that RSV induces vasodilatory effects in several vascular beds by acting in endothelium dependent and independent manners. The aim of the study was to determine the role of RSV on hypoxia induced vasoconstriction in precontracted isolated pulmonary arteries and veins. Isolated lamb pulmonary vessels were suspended in an organ bath filled with Krebs Heinseleit solution and isolated contractions were recorded continuously via an isometric transducer connected to a computerized polygraph system. The solution was aerated with room air or a gas mixture of 95% N-2 + 5% CO2 (hypoxic). The oxygen concentration of the bathing medium was measured using an oxygen electrode. Serotonin (5-HT)(10(-5) M) for arteries and U46619, a thromboxane analog (TXA2) for veins, were used as pre contractile agents. Our results showed that in the presence of RSV (20 mu M), hypoxia induced pulmonary vasoconstriction decreased in pulmonary veins pre contracted with U46619, but not in pulmonary arteries pre contracted with 5-HT.en_US
dc.identifier.endpage845en_US
dc.identifier.issn1300-6045
dc.identifier.issue6en_US
dc.identifier.startpage841en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5756
dc.identifier.volume15en_US
dc.identifier.wosWOS:000274088000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject5-HTen_US
dc.subjectHypoxiaen_US
dc.subjectPulmonary vasoconstrictionen_US
dc.subjectResveratrolen_US
dc.subjectU46619en_US
dc.titleEffect of Resveratrol in Acute Hypoxic Pulmonary Vasoconstriction in Isolated Lamb Pulmonary Arteries and Veinsen_US
dc.typeArticleen_US

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