Stepwise implementation of a low-cost and portable radiofrequency hyperthermia system for in vitro/in vivo cancer studies

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dc.authoridSenturk, Fatih/0000-0002-2436-3362
dc.authorwosidSenturk, Fatih/AAR-9444-2021
dc.contributor.authorSenturk, Fatih
dc.contributor.authorKocum, I. Cengiz
dc.contributor.authorOzturk, Goknur Guler
dc.date.accessioned2021-12-01T18:49:07Z
dc.date.available2021-12-01T18:49:07Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractIn recent years, interactions of radiofrequency (RF) electromagnetic fields with biological tissue have become one of the most promising strategies for noninvasive cancer hyperthermia treatment. Despite the growing interest, there has been a scarcity of studies involving the detailed construction of a complete RF-hyperthermia (RF-HT) system. Here a low-cost and high-power RF-HT system is reported with a specific frequency which can be used in biological samples. A laboratory-constructed RF-HT system composed of a radiofrequency oscillator, radiofrequency driver, radiofrequency amplifier, radiofrequency matching network, and an induction coil applicator were constructed and characterized by a stepwise approach. Although the RF driver and amplifier were purchased as professionally designed kits, significant modifications were required for these components. The results showed that the RF-HT system was successfully constructed and tested at 13.56 MHz with a power as high as 400 W. As a preliminary biological experiment, cell culture medium exhibited an approximate 3 degrees C increase in temperature induced by the RF-HT device at 250 W for 10 min. Moreover, the developed system is suitable drug targeting, drug release, and cellular uptake and designed to be cost-effective for in vitro/in vivo studies involving cancer therapy.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-118S027, SBAG-119S137]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) grant SBAG-118S027 and SBAG-119S137.en_US
dc.identifier.doi10.1080/10739149.2021.1927075
dc.identifier.endpage641en_US
dc.identifier.issn1073-9149
dc.identifier.issn1525-6030
dc.identifier.issue6en_US
dc.identifier.startpage629en_US
dc.identifier.urihttps://doi.org/10.1080/10739149.2021.1927075
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10668
dc.identifier.volume49en_US
dc.identifier.wosWOS:000653058900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofInstrumentation Science & Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject13.56 MHz generatoren_US
dc.subjectHyperthermia systemen_US
dc.subjectRadiofrequency (RF) amplifieren_US
dc.subjectRadiofrequency (RF) power generatoren_US
dc.subjectMagnetic Hyperthermiaen_US
dc.subjectNanoparticlesen_US
dc.subjectPrinciplesen_US
dc.titleStepwise implementation of a low-cost and portable radiofrequency hyperthermia system for in vitro/in vivo cancer studiesen_US
dc.typeArticleen_US

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