Evaluation of Acute and Subacute Toxicity of ISY-CP® Food Herbal Mixture in Rats

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dc.contributor.authorYaşar, Mustafa
dc.contributor.authorŞenoğul, Oğuzhan
dc.contributor.authorKaradeniz, Beste
dc.contributor.authorGök, Ali
dc.contributor.authorAğyar Yoldaş, Pınar
dc.contributor.authorAğan, Kağan
dc.date.accessioned2024-12-28T20:24:17Z
dc.date.available2024-12-28T20:24:17Z
dc.date.issued2020
dc.description.abstractObjective: Recently, there is a growing interest in medicinal and aromatic plants also the treatment methods by using these plants in traditional and complementary medicine. On the other hand, possible toxicities of medicinal and aromatic plants has lately begun to be researched and it is extremely important to cognize these possibilities for human consumption. Therefore, a research has been conducted to understand the acute/subacute toxicity characteristics of a plant based herbal mixture, ISY-CP® used in remember regeneration therapy method (RTM) in rats. The product contains a mixture of nettle leaves (Urtica dioica), yarrow (Achillea millefolium), thyme (Thymus vulgaris) and horsetail (Equisetum arvense) plants. The aim of this research was to examine the effects of ISY-CP® herbal mixture in term of toxicity. Material-Method: In the experimental design, 32 female rats were divided into 4 groups (control, acute, subacute and post-subacute). In order to observe acute and subacute toxicity, clinical observations were performed and the biochemical, hematological and histopathological parameters of the animals were evaluated at the end of the application. Results: According to the results obtained from the study, there were not found significant differences in biochemical, hematological and histopathological evaluations between the control and the application groups. Only phorphorus data is statistically different between subacute toxicity group and control group.Conclusion: In our study, the acute and subacute toxic effects of ISY-CP® herbal mixture’s doses used in this study were not observed.
dc.identifier.dergiparkDergiPark: 743285
dc.identifier.endpage60
dc.identifier.issn2717-7491
dc.identifier.issue2
dc.identifier.startpage54
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/1121327
dc.identifier.urihttps://dergipark.org.tr/tr/pub/ijtcmr/issue/56526/743285
dc.identifier.urihttps://hdl.handle.net/20.500.12684/17184
dc.identifier.volume1
dc.language.isoen
dc.publisherDüzce Üniversitesi
dc.relation.ispartofInternational Journal of Traditional and Complementary Medicine Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241228
dc.subjectTraditional and complementary medicine
dc.subjectacute toxicity
dc.subjectsubacute toxicity
dc.subjectUrtica dioica
dc.subjectAchillea millefolium
dc.subjectThymus vulgaris
dc.subjectEquisetum arvense
dc.subjectTraditional, Complementary and Integrative Medicine
dc.titleEvaluation of Acute and Subacute Toxicity of ISY-CP® Food Herbal Mixture in Rats
dc.typeArticle

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International Journal of Traditional and Complementary Medicine Research