Potential use of decorin in preventing cerebral vasospasm through the inhibition of transforming growth factor-beta activity: Insights from an experimental rabbit subarachnoid hemorrhage model

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dc.contributor.authorYaman, Betul
dc.contributor.authorGel, Gulce
dc.contributor.authorTuncer, Cengiz
dc.contributor.authorHanalioglu, Sahin
dc.contributor.authorBulut, Husamettin
dc.contributor.authorArikök, Ata Türker
dc.contributor.authorGürer, Bora
dc.date.accessioned2025-10-11T20:45:21Z
dc.date.available2025-10-11T20:45:21Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: The development of vasospasm after subarachnoid hemorrhage (SAH) is a major cause of death and disability. It leads to structural changes such as smooth muscle and myofibroblast proliferation, necrosis, intimal hyperplasia, and vascular fibrosis. Transforming growth factor-beta1 (TGF-β1) activates nonmuscular myofibroblasts, promoting cerebral vasoconstriction. Decorin, a natural TGF-β inhibitor, has not yet been evaluated for its potential to prevent SAH-induced vasospasm. This study aimed to investigate the effects of decorin on cerebral vasculopathy and hippocampal injury in a rabbit model of TGF-β-induced vasospasm. Methods: Thirty-two male New Zealand white rabbits (2.5–4 kg) were randomly assigned to four groups: control, SAH, decorin, and TGF-β1. Except for the control group, all underwent the SAH procedure. The decorin group received 100 μg/kg decorin intraperitoneally for 3 days; the TGF-β1 group received 50 μg TGF-β1 intracisternally in 1 cc autologous CSF. Animals were sacrificed at 72 h using perfusion–fixation. Basilar artery cross-sectional area, wall thickness, and hippocampal degeneration scores were assessed using histopathological and statistical analysis systems. Results: Based on statistical analyses, decorin treatment significantly increased the cross-sectional area of the basilar artery but significantly reduced the wall thicknesses compared with those in the SAH and TGF-β1 groups. Furthermore, hippocampal neuronal degeneration scores were significantly lower in the decorin and control groups than in the SAH and TGF-β1 groups. There were no significant differences between the groups in terms of proliferating cell nuclear antigen. Conclusion: Decorin treatment in rabbits with experimentally induced SAH ameliorated TGF-β1-induced vasospasm, cerebral vasculopathy associated with vascular wall fibrosis, and subsequent decreased vessel wall thickness. © 2025 Elsevier B.V., All rights reserved.en_US
dc.identifier.doi10.1016/j.wnsx.2025.100520
dc.identifier.issn2590-1397
dc.identifier.scopus2-s2.0-105016513800en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.wnsx.2025.100520
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21312
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofWorld Neurosurgery: Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250911
dc.subjectCerebral Arteriesen_US
dc.subjectDecorinen_US
dc.subjectHippocampusen_US
dc.subjectRabbiten_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.subjectTgf-β1en_US
dc.subjectVasospasmen_US
dc.subjectCyclineen_US
dc.subjectDecorinen_US
dc.subjectTransforming Growth Factor Beta1en_US
dc.subjectAnimal Cellen_US
dc.subjectAnimal Experimenten_US
dc.subjectAnimal Modelen_US
dc.subjectAnimal Tissueen_US
dc.subjectArterial Wall Thicknessen_US
dc.subjectArticleen_US
dc.subjectBasilar Arteryen_US
dc.subjectBrain Vasospasmen_US
dc.subjectCell Proliferationen_US
dc.subjectControlled Studyen_US
dc.subjectHippocampusen_US
dc.subjectHistopathologyen_US
dc.subjectMaleen_US
dc.subjectNerve Cell Degenerationen_US
dc.subjectNew Zealand White (rabbit)en_US
dc.subjectNonhumanen_US
dc.subjectSectional Anatomyen_US
dc.subjectSubarachnoid Hemorrhageen_US
dc.titlePotential use of decorin in preventing cerebral vasospasm through the inhibition of transforming growth factor-beta activity: Insights from an experimental rabbit subarachnoid hemorrhage modelen_US
dc.typeArticleen_US

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