Volumetric analysis of the brain structures of children with down’s syndrome: A 3D MRI study

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dc.authorscopusid6603849497
dc.authorscopusid14419755900
dc.authorscopusid57223212616
dc.authorscopusid34868115100
dc.authorscopusid7003525174
dc.authorscopusid36618340100
dc.contributor.authorOz, F.
dc.contributor.authorAcer, N.
dc.contributor.authorCeviz, Y.
dc.contributor.authorEroz, R.
dc.contributor.authorCanatan, H.
dc.contributor.authorYucekaya, B.
dc.date.accessioned2021-12-01T18:38:54Z
dc.date.available2021-12-01T18:38:54Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractDown’s syndrome (DS) is one of the most common genetic causes of mental and cognitive retardation. In fact, it results in a number of characteristic neuropsychological and physical symptoms, including mental retardation. The aim of this study was to compare the brain structure volumes of children with DS to those of healthy children using MRI Studio in order to investigate whether there exists correlation between the developmental stages of DS and the results of both the Denver II Developmental Screening Test and magnetic resonance imaging (MRI) quantitative analysis. Five children diagnosed with Down’s syndrome (age range = 2–6 years) were matched for gender and age with five healthy comparison subjects. To analyse the overall and regional brain volumes, high-resolution MRI scans were performed and a morphometric analysis was conducted via MRI Studio software. The MRI T1 volumetric images were normalised using a linear transformation, which was followed by large deformation diffeomorphic metric mapping. Significant decreases (p<0.05) in the volumes of the right pons, cerebellum and left superior frontal gyrus (prefrontal cortex) were observed in the children with DS when compared with the control group (p<0.05). Although decreases were detected in the regional volumes of other brain locations, they were not significant (p>0.05). It was further found that the developmental retardation observed in the children with DS, as detected using the Denver II test, increased due to decreases in the volumes of certain regions of the brain, although this was also not statistically significant (p>0.05). The results of this study generally confirm the findings of prior studies concerning the overall patterns of the brain volumes in children with DS and also provide new evidence of the abnormal volumes of specific regional tissue components among such a population. These results suggest that the brain volume reduction associated with DS may primarily be due to early developmental differences rather than neurodegenerative changes © 2021 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.description.sponsorship2013/4728en_US
dc.description.sponsorshipAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Written consent was obtained from the participants as per Erciyes University Ethical Board regulations (2013/413). This study has been supported by Erciyes University Scientific Research Projects Coordination Unit under grant number 2013/4728.en_US
dc.identifier.doi10.52142/omujecm.38.2.26
dc.identifier.endpage203en_US
dc.identifier.issn13094483
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85105282429en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.38.2.26
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9900
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain volumeen_US
dc.subjectDenver II testen_US
dc.subjectDown’s syndromeen_US
dc.subjectMRIen_US
dc.titleVolumetric analysis of the brain structures of children with down’s syndrome: A 3D MRI studyen_US
dc.typeArticleen_US

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