COMPARATIVE ANALYSIS OF MATURE AND PREPROPROTEIN FORM OF THIONINS IN SOME PLANT SPECIES; BIOINFORMATICS APPROACHES

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dc.contributor.authorÖzyiğit, İbrahim İlker
dc.contributor.authorFiliz, Ertuğrul
dc.contributor.authorSaraçoğlu, İbrahim Adnan
dc.contributor.authorYalçın, Bahattin
dc.date.accessioned2020-04-30T22:41:05Z
dc.date.available2020-04-30T22:41:05Z
dc.date.issued2019
dc.departmentDÜ, Çilimli Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümüen_US
dc.descriptionWOS: 000471836900075en_US
dc.description.abstractThionins are one of the most important antimicrobial peptides in broad-range plant defense. A number of studies are present regarding the structural and biological role of mature thionins but preproprotein forms of these molecules have not been extensively studied. Thus, this study aimed to comparatively analyze a total of 56 thionin preproprotein sequences from 14 different plant species. Analyses of primary, secondary and tertiary structures of these forms revealed that preproproteins with "gamma-thionin domain" were relatively shorter and more basic than proteins with "thionin domain" structure. In addition, members of "thionin domain" were more similar to each other than that of "gamma-thionin domain" forms. Sub-cellular localizations of these forms were predicted as extracellular. Structural superposition of precursor and mature thionins showed that a large portion of precursor sequences are cleaved to form a functional protein. Although precursor forms demonstrated the significant structural divergence in modelled species, functional mature forms showed a structural pattern in alpha-helices; two alpha-helix proteins included the "thionin domain" family while one a-helix proteins contained the "gamma-thionin domain" family. Results of this study will become valuable theoretical knowledge and provide insight in terms of further understanding the formation of mature functional thionins thereby their biological roles.en_US
dc.identifier.endpage4266en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue5en_US
dc.identifier.startpage4256en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3120
dc.identifier.volume28en_US
dc.identifier.wosWOS:000471836900075en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha/beta-thioninsen_US
dc.subjectgamma-thioninsen_US
dc.subjectdisulfide bridgesen_US
dc.subject3D modelingen_US
dc.subjectplant defenseen_US
dc.titleCOMPARATIVE ANALYSIS OF MATURE AND PREPROPROTEIN FORM OF THIONINS IN SOME PLANT SPECIES; BIOINFORMATICS APPROACHESen_US
dc.typeArticleen_US

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