Is there an Advantage of Subchondral Drilling and Bone Marrow to Hyaluronic Acid Injection at Rabbit's Knee Osteoarthritis? An Experimental Study
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Tarih
2021
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The objective of this study is to compare the individual histopathological changes caused by subchondral drilling (SCD) and bone marrow injection accompanied by hyaluronic acid (HA) in rabbits with knee osteoarthritis (OA) that is stimulated by the anterior cruciate ligament transection. Method: An OA design was created in 20 New Zealand rabbits, which were then randomly divided into two groups of ten rabbits each. The first group was named as the SCD group, in which 0.3 mL bone marrow aspirate was taken from the proximal medial tibial region and injected into the same knee joint; thereafter, retrograde SCD was applied to the proximal tibial region. The second group (HA) received intra-articular injections of 0.3 mL HA oil once weekly for three weeks. The knee joints were removed nine weeks post-surgery after the animals were killed. The knee joint articular cartilage areas were examined macroscopically, and the medial femoral condyle sections were examined histopathologically. Results: Significantly better macroscopic grading results were observed in the SCD group than in the HA group (p = 0.0001). There was no significant difference in the OA cartilage histopathology (OACH) grade between the groups (p = 0.752), but the SCD group showed a significantly better OACH stage result than the HA group (p = 0.039). The total OACH score inclined to be lower in the SCD group than in the HA group (p = 0.192). Conclusion: This study demonstrated that SCD with intra-articular bone marrow injection slowed the progression of OA and protected the cartilage surface during the early stages of OA better than HA.
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Kaynak
İstanbul Kanuni Sultan Süleyman Tıp Dergisi
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Cilt
13
Sayı
2
