Son 10 yılda kliniğimizde takip edilen liken planus olgularının retrospektif değerlendirilmesi
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Dosyalar
Tarih
2012
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Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Liken planus deri ve mukoz membranları tutan papüloskuamöz bir hastalıktır. Etyoloji ve patogenezi tam olarak bilinmemektedir. Mevsimsel değişikliklerin yanı sıra psikolojik stres, viral hastalıklar, otoimmünite ve kontakt alerjenler hastalığın ortaya çıkışında etkili olabilir. Çalışmamızın amacı bölgemizde görülen liken planus olgularının klinik-demografik özelliklerini ve mevsimsel dağılımını ortaya koymaktır. Gereç ve Yöntem: Çalışmamızda Düzce Üniversitesi Tıp Fakültesi Araştırma Uygulama Hastanesi Dermatoloji Anabilim Dalı Polikliniğinde Ocak 2000-Mayıs 2010 tarihleri arasında liken planus tanısı konulan 191 hastanın dosyaları geriye dönük olarak değerlendirildi. Bulgular: Polikliniğimize başvuran tüm hastaların %0,68’i liken planus hastasıydı. Hastaların yaşı 9 ile 80 yaş arasında değişmekteydi. Yaş ortalaması 44,61,2 yaş olup ortanca değeri 45 idi. Kadın ve erkeklerde görülme sıklığı eşitti. Mevsimsel dağılım incelendiğinde kış ve ilkbahar aylarında daha fazla başvuru olduğu gözlendi. Hastaların %73,8‘inde deri tutulumu, %33’ünde oral mukoza tutulumu, %11,6’sında genital tutulum saptandı. Deri tutulumu olan hastaların %24,8’inde oral tutulum da olduğu gözlendi. İzole oral tutulum oranı ise %14,7 olarak bulundu. Sonuç: Çalışmamızda liken planus hastalarında cinsiyet farklılığının olmaması, ilkbahar ve kış aylarında liken planus sıklığında artış, oral ve genital tutulum oranlarının diğer çalışmalara oranla düşük olması gibi farklı sonuçlar elde edilmiştir. Mevsimsel faktörlerin hastalığın farklı parametreleri üzerine etkilerinin tam olarak anlaşılabilmesi için ülkemizde benzer çalışmalara ihtiyaç bulunmaktadır.
Objective: Lichen planus is a papulosquamous disease that affects skin and mucous membranes. The etiology and pathogenesis of lichen planus is not well known. Psychological stress, viral diseases, auto-immunity, and contact allergens as well as seasonal changes may have a role on the occurrence of the disease. The aim of this study was to investigate clinical, demographic characteristics and seasonal distribution of lichen planus in our region. Methods: We reviewed the records of 191 patients with lichen planus who were followed up in Dermatology Department of Düzce University Medical Faculty between January 2000 and May 2010, retrospectively. Results: Lichen planus patients comprised 0.68 percent of all patients who attended to our clinic. Their ages ranged from 9 to 80 years and the mean age was 44,6±1,2 years with the median value of 45 years. The incidence of lichen planus in men and women was equal. Admissions to the clinic was observed more in winter and spring seasons. Skin involvement, oral mucosa involvement, and genital involvement were found in 73.8%, 33%, and 11.6% of the patients, respectively. 24.8% of the patients with skin involvement had also oral mucosa involvement. The rate of isolated oral involvement was found to be 14.7%. Conclusion: In our study, some different results such as no sex predilection in lichen planus patients increase in frequency of lichen planus in spring and winter seasons, lower rates of oral and genital involvements with respect to other studies were obtained. It is clear that similar studies from other regions of our country are needed to better understand the effects of seasonal factors on different parameters of the disease.
Objective: Lichen planus is a papulosquamous disease that affects skin and mucous membranes. The etiology and pathogenesis of lichen planus is not well known. Psychological stress, viral diseases, auto-immunity, and contact allergens as well as seasonal changes may have a role on the occurrence of the disease. The aim of this study was to investigate clinical, demographic characteristics and seasonal distribution of lichen planus in our region. Methods: We reviewed the records of 191 patients with lichen planus who were followed up in Dermatology Department of Düzce University Medical Faculty between January 2000 and May 2010, retrospectively. Results: Lichen planus patients comprised 0.68 percent of all patients who attended to our clinic. Their ages ranged from 9 to 80 years and the mean age was 44,6±1,2 years with the median value of 45 years. The incidence of lichen planus in men and women was equal. Admissions to the clinic was observed more in winter and spring seasons. Skin involvement, oral mucosa involvement, and genital involvement were found in 73.8%, 33%, and 11.6% of the patients, respectively. 24.8% of the patients with skin involvement had also oral mucosa involvement. The rate of isolated oral involvement was found to be 14.7%. Conclusion: In our study, some different results such as no sex predilection in lichen planus patients increase in frequency of lichen planus in spring and winter seasons, lower rates of oral and genital involvements with respect to other studies were obtained. It is clear that similar studies from other regions of our country are needed to better understand the effects of seasonal factors on different parameters of the disease.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Tıp Araştırmaları Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
1
