a-Galactosidase levels in irritable bowel syndrome subtypes and quality of life of patients

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dc.contributor.authorErmiş, Fatih
dc.contributor.authorSoysal, Tuba
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2023-07-26T11:54:54Z
dc.date.available2023-07-26T11:54:54Z
dc.date.issued2021
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: There is a requirement for a reliable serologic marker that can be used for the diagnosis of Irritable Bowel Syndrome (IBS). The aim of our study was to research whether serum levels of Alpha-galactosidase (AG) is associated with IBS and to assess quality of life (QOL) of IBS patients. Materials and Methods: 110 adult patients who were diagnosed with IBS were evaluated. 90 patients and 25 healthy volunteers were included. Patients were classified into subtypes: IBS-Diarrhea (IBS-D), IBS-Constipation (IBS-C), IBS-Mixed (IBS-M), and 30 patients were enrolled for each group. We administered the Short Form 36 (SF-36) to participants to evaluate QOL. Serum AG levels of participants was determined. Results: The mean AG levels of IBS-C and control group were significantly lower than the other groups (p<0.05). The SF-36 questionnaire scores, except for the vitality and mental health domains, were higher significantly in the control group compared to IBS patients (p<0.05). The mean scores of IBS subtypes were similar. In addition, the mean physical functioning score of the control group was higher in comparison with the IBS-D group significantly (p<0.05). Conclusion: Our study has shown that IBS impairs QOL in patients. In addition, we suggest that future studies needed for the role of AG deficiency in IBS patients.en_US
dc.identifier.doi10.5455/annalsmedres.2020.11.1132
dc.identifier.endpage1886en_US
dc.identifier.issn2636-7688
dc.identifier.issue10en_US
dc.identifier.startpage1881en_US
dc.identifier.trdizinid482662en_US
dc.identifier.urihttp://doi.org/10.5455/annalsmedres.2020.11.1132
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/482662
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12952
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorErmiş, Fatih
dc.institutionauthorSoysal, Tuba
dc.institutionauthorAnkaralı, Handan
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.titlea-Galactosidase levels in irritable bowel syndrome subtypes and quality of life of patientsen_US
dc.typeArticleen_US

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