Prospective Case—Controlled Study of Endothelial Function in Patients with Mild to Moderate Psoriasis
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı orta derecede psöriyazisi olan hastalarda endotelyel disfonksiyonu varlığınıinvaziv olmayan yöntemlerle araştırmaktır. Gereç ve yöntemler: Elli üç psöriyazisli hasta ve 53 sağlıklı birey çalışmaya dâhil edildi. Çalışmaya dahil edilen tüm hasta ve kontrol grubunun karotid arter intima--medya kalınlığı ve brakiyal arterin akım aracılı dilatasyonu ölçüldü. Bulgular: Çalışmaya dahil edilen tüm hastaların ortalama yaş, cinsiyet, vücut kitle indeksi, sigara alışkanlığı, antropometrik ölçümler ve arteryel kan basınçlarının hem psöriyazisli hasta hem de kontrol grubunda benzer olduğu görüldü. Hasta grubu değerlendirildiğinde ortalama psöriyazis alanı ve şiddet indeks skorunun 6.35:6.81 oldugu görüldü. Kontrol grubu ile karşılaştırıldığında hasta grubunda trigliserid seviyesi anlamlı olarak daha yüksekti (p0.05), lipoprotein kolesterol seviyesi ise anlamlı olarak daha düşüktü (p0.05). Hasta grubunda insülin direnci kontrol grubuna oranla istatistiksel olarak daha yüksek bulundu (p0.05). Hem psöriyazisli hasta grubunda hem de kontrol grubunda karotid arter intima--medya kalınlığı açısından anlamlı bir fark yoktu (p0.05); ancak akım aracılı dilatasyonu hasta grubunda kontrole oranla istatistiksel olarak daha düşük bulundu (p0.05). Serbest T3 seviyesi de hasta grubunda kontrol grubuna göre istatistiksel olarak daha düşük bulundu (p0.05). Sonuçlar: Bu çalışma ile düşük aktiviteli psöriyatik hastalarda, klinik olarak kardiyovasküler hastalık saptanmamış olsa bile endotelyel disfonksiyonunun olabileceğini gösterilmiştir. Ayrıca bu çalışma ile psöriyatik hasta grubunda insülin direncininin olduğu da gösterilmiştir. Tiroid fonksiyon testleri kardiyovasküler risk hakkında ilave bilgi sağlayabilir.
Aim: The aim of this study is to investigate endothelial dysfunction in psoriasis patients with non-invasive methods. Materials and Methods: Fifty—three psoriasis patients and 53 healthy individuals were included in the study. Carotid artery intimae—media thickness and brachial artery flow-mediated dilation was measured both in patient and control groups. Results: Mean age, gender, body mass index, smoking habits, anthropometric measurements and arterial blood pressure values were similar in both groups. Mean psoriasis area and severity index score of psoriasis patients was 6.35:6.81. Triglyceride level was significantly higher (p0.05) and high density lipoprotein cholesterol level was significantly lower (p 0.05) in psoriasis patients when compared with the controls. Insulin resistance was found to be statistically higher in psoriasis patients group than the control group (p0.05). There was no significant differences between two groups in terms of carotid artery intimae—media thickness (p0.05); but flow—mediated dilation was found to be statistically significantly lower in psoriasis patients than the control group (p0.05). FT3 level was also found to be statistically significantly lower in psoriasis patients than the control group (p0.05). Conclusion: This study showed endothelial dysfunction and insulin resistance in psoriasis patients with low disease activity even in the absence of clinical cardiovascular disease. Thyroid function tests could supply information about cardiovascular risk.
Aim: The aim of this study is to investigate endothelial dysfunction in psoriasis patients with non-invasive methods. Materials and Methods: Fifty—three psoriasis patients and 53 healthy individuals were included in the study. Carotid artery intimae—media thickness and brachial artery flow-mediated dilation was measured both in patient and control groups. Results: Mean age, gender, body mass index, smoking habits, anthropometric measurements and arterial blood pressure values were similar in both groups. Mean psoriasis area and severity index score of psoriasis patients was 6.35:6.81. Triglyceride level was significantly higher (p0.05) and high density lipoprotein cholesterol level was significantly lower (p 0.05) in psoriasis patients when compared with the controls. Insulin resistance was found to be statistically higher in psoriasis patients group than the control group (p0.05). There was no significant differences between two groups in terms of carotid artery intimae—media thickness (p0.05); but flow—mediated dilation was found to be statistically significantly lower in psoriasis patients than the control group (p0.05). FT3 level was also found to be statistically significantly lower in psoriasis patients than the control group (p0.05). Conclusion: This study showed endothelial dysfunction and insulin resistance in psoriasis patients with low disease activity even in the absence of clinical cardiovascular disease. Thyroid function tests could supply information about cardiovascular risk.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
20
Sayı
2
