Effect of Taurine on Experimental Facial Paralysis and Dry Eye in Rats

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dc.contributor.authorKoc, Haci
dc.contributor.authorKoçak, Ibrahim
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorKale, Saim
dc.contributor.authorGök, Ali
dc.contributor.authorDemir, Şerif
dc.date.accessioned2025-10-11T20:45:26Z
dc.date.available2025-10-11T20:45:26Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAim: This study aimed to evaluate dry eye development and the efficacy of taurine for dry eye treatment in a rat model with facial paralysis. Material and Methods: Thirty-two rats were divided into four groups with eight rats in each. The rats in groups 2, 3, and 4 underwent facial paralysis surgically, while the rats in group 1 remained as controls. The rats in group 2 did not receive any treatment. Group 3 was treated with 0.2% sodium hyaluronate, and group 4 was treated with 0.2% sodium hyaluronate and 0.5% taurine. The results of the first and last Schirmer’s tests were compared. Results: When the Schirmer’s tests were performed in rats with facial paralysis under general anesthesia to detect dry eye, the scores were low, indicating that general anesthesia increased dry eye in all groups. Thus, Schirmer’s tests were performed without general anesthesia. The final test results were significantly different between groups (p=0.001). Pairwise comparisons revealed that there was a significant decrease in groups 2 (p=0.001) and 3 (p=0.002) compared to the control group. Group 4 was similar to the control group (p=0.304) and had a significant improvement compared to group 2 (p=0.037). No statistically significant difference was found between groups 2 and 4 (p=0.566). Conclusion: Taurine seems to have the potential to be effective in relieving dry eye symptoms. This could be related to the dominantly antioxidant effect of taurine. These results warrant further studies with larger sample size to determine the effectiveness of taurine for dry eye treatment. © 2025 Elsevier B.V., All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1612612
dc.identifier.endpage122en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-105014636064en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1612612
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21356
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250911
dc.subjectDry Eyeen_US
dc.subjectFacial Paralysisen_US
dc.subjectSchirmer’s Testen_US
dc.subjectTaurineen_US
dc.subjectTaurineen_US
dc.subjectAntioxidanten_US
dc.subjectTaurineen_US
dc.subjectAnimal Experimenten_US
dc.subjectAnimal Modelen_US
dc.subjectAnimal Tissueen_US
dc.subjectArticleen_US
dc.subjectControlled Studyen_US
dc.subjectDry Eyeen_US
dc.subjectEye Developmenten_US
dc.subjectFacial Nerve Paralysisen_US
dc.subjectGeneral Anesthesiaen_US
dc.subjectHistologyen_US
dc.subjectNonhumanen_US
dc.subjectProtein Expressionen_US
dc.subjectRaten_US
dc.subjectSchirmer Testen_US
dc.titleEffect of Taurine on Experimental Facial Paralysis and Dry Eye in Ratsen_US
dc.title.alternativeTaurinin Sıçanlarda Deneysel Fasyal Paralizi ve Kuru Göz Üzerine Etkisien_US
dc.typeArticleen_US

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