The effects of vildagliptin in liver functions in type 2 diabetic patients

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dc.contributor.authorGökosmanoğlu, Feyzi
dc.contributor.authorÖnmez, Attila
dc.contributor.authorTopkaya, Sibel
dc.date.accessioned2020-04-30T23:33:34Z
dc.date.available2020-04-30T23:33:34Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000512905300002en_US
dc.description.abstractAim: In Type 2 diabetic patients, the prevalence of liver disease is high when compared with the general population. For this reason, the hepatic safety of anti-diabetes agent is important. However, there are uncertainties about the long-term efficiency and reliability of vildagliptin treatment. In this study, we have reviewed the findings obtained from the clinical use of vildagliptin and its effects on the liver. Material and Method: The study was conducted on 243 patients who were followed-up in our clinic between September 2016 and May 2018. The data were obtained by reviewing the patient files retrospectively. Result: A decrease was detected in the aminotransferases after the treatment with vildagliptin, which was statistically significant (ALT: decreased from 78 +/- 17 to 48 +/- 14 IU/L (p = 0.029), AST: decreased from 63 +/- 13 to 41 +/- 11 IU/L (p=0.035); GGT: 20.5 +/- 3.2 and 19.1 +/- 6.3 (p=0.682)). Vildagliptin reduces the insulin resistance and Body Mass Index in patients. Discussion: It was determined that Vildagliptin is a safe treatment option for Type 2 Diabetes management.en_US
dc.identifier.doi10.4328/ACAM.5983en_US
dc.identifier.endpage531en_US
dc.identifier.issn2667-663X
dc.identifier.issue5en_US
dc.identifier.startpage529en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.5983
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5000
dc.identifier.volume10en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals Of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectType 2 Diabetesen_US
dc.subjectVildagliptinen_US
dc.subjectSafetyen_US
dc.subjectLiver Functionsen_US
dc.titleThe effects of vildagliptin in liver functions in type 2 diabetic patientsen_US
dc.typeArticleen_US

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