Alfa lipoik asit kullanan diyabetik nöropatili hastalarda sinir ileti çalışmalarının değerlendirilmesi
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Dosyalar
Tarih
2009
Yazarlar
Dergi Başlığı
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Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş ve amaç: Alfa Lipoik Asit'in kişiler ve deneysel diyabetikler üzerindeki çalışma sonuçlarının sinir iletimini geliştirmesi ve önlemesi nedeniyle, 1 aylık peryotta sinir iletim çalışmaları ve semptomlar üzerinde alfa lipoik asidin etkinliğini belirlemeyi amaçladıkYöntem: Bu çalışma sensorimotor semptomlu metobolik olarak stabil ve kontrol altındaki 20 diyabetik hastayı kapsamaktadır. Her hasta için nöropati semptom skoru ve sinir ileti çalışmaları kaydedildi. 20 poliklinik hastasına rutin takip ve tedavi protokollerine ilaveten 1 ay boyunca oral olarak günde 1 kez 600 mg alfa lipoik asit tedavisi verildi. 1 ay sonra diyabetik nöropati semptom skoru ve sinir ileti çalışmalarındaki değişim belirlendiBulgular: Diyabetik nöropati semptom skorlarında düzelme bulundu (p<0.001).İkinci değerlendirmedeki sinir ileti çalışma sonuçları birincisiyle benzer olmasına rağmen hastaların çoğunda ikinci değerlendirmede daha iyi sonuçlar gözlendi. HbA1c ve kan glikoz düzeyleri ikinci olçümlerde farklıydı (sırasıyla p: 0.003 ve p: 0.001). Diyabetik nöropati semptom skorları, HbA1c ve kan glikoz düzeyleriyle koreleydi (p<0.001Sonuç: Potent bir antioksidan olan alfa lipoik asit hızlı ve önemli ölçüde duysal semptomları düzeltti. Hastaların rutin terapötik ajanlar ve alfa lipoik aside ek olarak herhangi başka bir ajan kullanmaması nedeniyle oral alfa lipoik asidin kan glikoz düzeyi ve semptomların kontrolüne yardımcı olması, sinir patofizyolojisine katkıda bulunan değişmelere bağlandı. Diyabetik nöropatilerde sinir ileti problemlerini tersine çevirme veya yavaşlatabilme etkisini gözlemlemek için oral alfa lipoik asit tedavisi ile nöropatik defisitlere odaklı uzun süreli çalışmalara ihtiyaç vardır
Introduction: Because alpha-lipoic acid prevents or improve nerve conduction study results in experimental diabetes and in humans, we aimed to assess the efficacy of alpha-lipoic acid on the symptoms and nerve conduction studies during 1 month periodMaterials and Methods: Metabolically stable and under control 20 diabetic patients with sensoriomotor symptoms were included in this study. Diabetic Neuropathy Symptom score and attributes of nerve conduction studies were recorded for every patient. Twenty outpatients were assigned to treatment with 600 mg alpha-lipoic acid once a day orally for 1 month in addition to routine follow-up and therapy protocols. After 1 month, we assessed the change of the Diabetic Neuropathy Symptom and nerve conduction study resultsResults: The improvement was found for Diabetic Neuropathy Symptom Scores (p<0.001). Although the nerve conduction study results of the second evaluation was similar to the first one, most of the patients showed better results in the second evaluation. The HbA1c and blood glucose levels were different in the second measurements (p=0.03 and p=0.001 respectively). The Diabetic Neuropathy Symptom Scores was correlated with the HbA1c and blood glucose levels (p<0.001Conclusions: Alpha-lipoic acid, a potent antioxidant, rapidly and to a significant degree, improved sensory symptoms. Because the patients did not used any other agents added to the routine therapeutic agents and alpha-lipoic acid, we concluded that oral alpha-lipoic acid also helped the control of blood glucose level and the control of symptoms was dependent to the changes attributed to improved nerve pathophysiology. Long-term trials that focus on neuropathic de ? cits are needed to see whether oral treatment with alpha-lipoic acid over several years may slow or reverse the nerve conduction problems of diabetic neuropathy
Introduction: Because alpha-lipoic acid prevents or improve nerve conduction study results in experimental diabetes and in humans, we aimed to assess the efficacy of alpha-lipoic acid on the symptoms and nerve conduction studies during 1 month periodMaterials and Methods: Metabolically stable and under control 20 diabetic patients with sensoriomotor symptoms were included in this study. Diabetic Neuropathy Symptom score and attributes of nerve conduction studies were recorded for every patient. Twenty outpatients were assigned to treatment with 600 mg alpha-lipoic acid once a day orally for 1 month in addition to routine follow-up and therapy protocols. After 1 month, we assessed the change of the Diabetic Neuropathy Symptom and nerve conduction study resultsResults: The improvement was found for Diabetic Neuropathy Symptom Scores (p<0.001). Although the nerve conduction study results of the second evaluation was similar to the first one, most of the patients showed better results in the second evaluation. The HbA1c and blood glucose levels were different in the second measurements (p=0.03 and p=0.001 respectively). The Diabetic Neuropathy Symptom Scores was correlated with the HbA1c and blood glucose levels (p<0.001Conclusions: Alpha-lipoic acid, a potent antioxidant, rapidly and to a significant degree, improved sensory symptoms. Because the patients did not used any other agents added to the routine therapeutic agents and alpha-lipoic acid, we concluded that oral alpha-lipoic acid also helped the control of blood glucose level and the control of symptoms was dependent to the changes attributed to improved nerve pathophysiology. Long-term trials that focus on neuropathic de ? cits are needed to see whether oral treatment with alpha-lipoic acid over several years may slow or reverse the nerve conduction problems of diabetic neuropathy
Açıklama
YÖK Tez No: 236435
Anahtar Kelimeler
Nöroloji, Neurology, Belirti ve semptomlar, Signs and symptoms, Diabetes mellitus, Diabetes mellitus, Diabetik nöropatiler, Diabetic neuropathies, Hemoglobin A-glikolize, Hemoglobin A-glycosylated, Kan glükozu, Blood glucose, Lipoik asit, Lipoic acid, Sinir lifleri, Nerve fibers, Diyabetik nöropati, alfa lipoik asit, sinir ileti çalışmaları, diyabetik nöropati semptom skoru, HbA1c, kan glikoz düzeyi, Diabetic neuropathy, alpha-lipoic acid, nerve conduction study, Diabetic Neuropathy Symptom score, HbA1c, blood glucose level
