The investigation of lipoprotein-related phospholipase A2 (LP-PLA2) V279F mutation in coronary artery disease

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dc.contributor.authorYıldırım Yaroğlu, Hatice
dc.contributor.authorAkciğer, Nazli
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorYılmaz, Dilek Cicek
dc.contributor.authorTamer, Lulufer
dc.date.accessioned2024-08-23T16:07:45Z
dc.date.available2024-08-23T16:07:45Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAim: Despite advances in the treatment of cardiovascular diseases, coronary artery disease (CAD) is the leading cause of death worldwide. The media layer of normal and diseased arteries contains lipoprotein-associated phospholipase A2 (Lp-PLA2), which is mostly made by mast cells, T lymphocytes, and monocytes. Our research aimed to define how the Lp-PLA2 and V279F gene polymorphisms are related to CAD. Materials and Methods: This study included 109 CAD patients and 71 controls. Fasting blood glucose (FBG) and lipid profiles were measured via the enzymatic colorimetric technique. Lp-PLA2 levels were detected with ELISA. The genomic DNAs were isolated from whole blood. Real-time polymerase chain reaction (RT-PCR) with the V279F mutation detection kit was used to identify the Lp-PLA2 V279F mutation. Results: In the CAD group compared to controls, serum Lp-PLA2 levels were higher (p=0.001). While FF (mutant) genotypes and VF (heterozygous) genotypes were absent in both groups, the Lp-PLA2 V279F mutation was discovered as the VV (wild) genotype in both the CAD group and controls. Conclusion: As a result, we determined that the Lp-PLA2 V279F mutation cannot be considered a genetic risk factor for CAD, but that Lp-PLA2 elevation may be an important parameter for CAD. Keywords: Lp-PLA2, Coronary artery disease, V279F.en_US
dc.identifier.doi10.5455/annalsmedres.2023.08.182
dc.identifier.endpage1222en_US
dc.identifier.issn2636-7688
dc.identifier.issue10en_US
dc.identifier.startpage1217en_US
dc.identifier.trdizinid1204271en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2023.08.182
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1204271
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14830
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe investigation of lipoprotein-related phospholipase A2 (LP-PLA2) V279F mutation in coronary artery diseaseen_US
dc.typeArticleen_US

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