Do Pediatric Patients with Familial Mediterranean Fever who have Phenotypically Predominant Arthritis, Arthralgia, and Myalgia Reflect a More Serious Underlying Disease than Those with Phenotypically Predominant Abdominal Pain?

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dc.contributor.authorKutlu Beseren, Tugba Nur
dc.contributor.authorErgüven, Müferet
dc.contributor.authorÜstebay, Sefer
dc.date.accessioned2025-10-11T20:37:53Z
dc.date.available2025-10-11T20:37:53Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAim: The study aimed to determine the presence of different de - mographic, familial, clinical, laboratory, and genotypic characteris- tics between children with Familial Mediterranean Fever (FMF) with recurrent arthritis, arthralgia, and myalgia phenotype and children with FMF with recurrent abdominal attacks phenotype. Material and Method: The study included patients who were ad - mitted to the Pediatric Rheumatology Outpatient Clinic of the Kafkas University Research Hospital before 2020, who were diagnosed with FMF and followed up for at least 1 year, and who were diagnosed with clinically recurrent arthritis, arthralgia, myalgia, and recurrent abdomi- nal pain. Patients were divided into two groups: 151 patients with re- current arthritis, arthralgia, and myalgia with FMF phenotypic features (Group 1) and 102 patients with recurrent diffuse, incomplete perito- neal involvement with predominant FMF phenotypic features (Group 2). The demographic and familial characteristics, age at diagnosis, and other clinical, laboratory, and genetic features of these 2 groups were compared, and the differences were statistically evaluated. Results: While 60.6% of the patients in Group 1 and 39.4% in Group 2 were female, 58.7% of the patients in Group 1 and 41.3% in Group 2 were male. No significant statistical difference was found between the two groups. When the groups were compared regarding genetic mutations, M694V homozygotes were observed in 17.2% of Group 1 and 8.8% of Group 2. There was a statistically significant difference between Group 1 and Group 2 in M694V homozygotes (p<0.05) Conclusion: Patients with FMF with predominant recurrent arthri- tis, arthralgia, and myalgia tended to be diagnosed at an older age and exhibited more frequent symptoms such as pallor and nausea compared to patients with FMF who predominantly had peritoneal involvement. Furthermore, pleural involvement was frequently ob- served, and the co-occurrence with the homozygous M694V mu- tation was genotypically high.en_US
dc.identifier.doi10.5505/kjms.2024.55770
dc.identifier.endpage289en_US
dc.identifier.issn2146-2631
dc.identifier.issn2587-053X
dc.identifier.issue3en_US
dc.identifier.startpage284en_US
dc.identifier.trdizinid1298840en_US
dc.identifier.urihttps://doi.org/10.5505/kjms.2024.55770
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1298840
dc.identifier.urihttps://hdl.handle.net/20.500.12684/20735
dc.identifier.volume14en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofKafkas Tıp Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250911
dc.subjectInvolvementen_US
dc.subjectarthritisen_US
dc.subjectmyalgiaen_US
dc.subjectarthralgiaen_US
dc.subjectfamilial Mediterranean feveren_US
dc.titleDo Pediatric Patients with Familial Mediterranean Fever who have Phenotypically Predominant Arthritis, Arthralgia, and Myalgia Reflect a More Serious Underlying Disease than Those with Phenotypically Predominant Abdominal Pain?en_US
dc.typeArticleen_US

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