The Preventative Effect of ?-Tocopherol on Spinal Epidural Fibrosis After Laminectomy in a Rat Model
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Tarih
2019
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info:eu-repo/semantics/openAccess
Özet
AIM: To assess the efficacy of ?-tocopherol as a topical antifibrotic agent on epidural fibrosis in lumbar laminectomy procedures.MATERIAL and METHODS: A total of 32 adult rats were assigned into four groups, with eight rats in each group. Standardlaminectomy was performed in every rat. In group 1, no treatment was administered after laminectomy. In group 2, a saline-soakedabsorbable gelatin sponge was left on the dura mater after laminectomy. In group 3, only ?-tocopherol was used on the dura materafter laminectomy. In group 4, a gelatin sponge soaked with ?-tocopherol was used after laminectomy. En bloc vertebral columnsbetween T10 and L5 were removed after sacrifice on postoperative day 30. Specimens were evaluated for degree of fibrosis andarachnoidal invasions.RESULTS: Statistically significant differences were found in the mean of fibrosis grades between groups (p=0.001). Differences inmean arachnoidal invasion were not statistically significant (p>0.05).CONCLUSION: Topical application of ?-tocopherol could effectively reduce the development of epidural fibrosis in an experimentallaminectomy model.
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Turkish Neurosurgery
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Cilt
29
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1
