Resistin predicts ischemia in myocardial perfusion scintigraphy

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dc.contributor.authorYıldırım, Mustafa
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorAşık, Muhammet
dc.contributor.authorUçgun, Taner
dc.contributor.authorYılmaz, Ayşe
dc.contributor.authorİlçe, Huri Tilla
dc.contributor.authorDoğan, Ahmet Semih
dc.date.accessioned2020-04-30T14:39:11Z
dc.date.available2020-04-30T14:39:11Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Resistin plays a role in the pathogenesis of coronary artery disease and is related to mortality and morbidity through a number of mechanisms. We hypothesize that plasma resistin levels are increased in the presence of ischemia, as measured by GATED singlephoton emission computed tomography myocardial perfusion scintigraphy (SPECT MPS), in comparison with nonischemic subjects. Materials and methods: Fasting intravenous blood samples of patients were drawn before a stress test. An ELISA kit was used for the assays. All patients underwent a technetium 99m-sestamibi GATED SPECT MPS study with a 1-day stress-rest protocol. Images were analyzed visually and patients were assessed as ischemic or nonischemic. Resistin levels were presented as medians (25th75th percentiles) and were compared using the MannWhitney U test. Results: Plasma resistin levels were higher in the ischemic group (n 47) than in the nonischemic group (n 67) [9.04 µmol/L (6.2711.8 µmol/L) vs. 3.56 µmol/L (0.397.93 µmol/L), respectively; P < 0.001). We showed that plasma resistin levels (OR 1.26, 95% CI: 1.131.41; P < 0.001) and METs (OR 0.82, 95% CI: 0.700.92; P 0.021) were independent predictors of ischemia. No linear correlation was found between plasma resistin levels and GATED SPECT or stress test parameters. Conclusion: Increased baseline resistin levels are independently related to presence of ischemia but are not related to the extent or severity of ischemia, or other functional parameters such as poststress ejection fraction, end systolic, and end diastolic volumes.en_US
dc.identifier.endpage500en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpFek1UQTBOQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/1312
dc.identifier.volume44en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleResistin predicts ischemia in myocardial perfusion scintigraphyen_US
dc.typeArticleen_US

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