Evaluation of Visfatin in Patients with Obesity, Metabolic Syndrome, Insulin Resistance and Impaired Glucose Tolerance; Case-Control Study

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dc.contributor.authorBaltacı, Davut
dc.contributor.authorTuncel, Mert Can
dc.contributor.authorÇetinkaya, Mert
dc.contributor.authorGündüz, Muhammet Talha
dc.contributor.authorÖzbey, Zemze
dc.contributor.authorAdmış, Özlem
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-04-30T14:39:13Z
dc.date.available2020-04-30T14:39:13Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Visfatin is a novel adipokine originally described to be produced predominantly by visceral fat tissue. The aim of the study was aimed to investigate visfatin level in non-diabetic obese patients with or without MetS and prediabetes.Methods: The cross-sectional study enrolled 169 subjects. Anthropometric measures and metabolic parameters were obtained. Exclusion criteria were pregnancy, smoking, any of the chronic disease. Blood sample was collected overnight fasting and centrifuged, and stored at refrigerator at -70º degree until to be assayed. Visfatin was assayed with ELISA method.Results: The study enrolled 169 subjects aged 36.9 ± 8.5 years (control group 52 and obese group: 117; and Male: 28 and Female: 141). Among obese subjects, the frequency of MetS, and PreDM was respectively 35.1% (n 41) and 70.1% (n 82). Mean concentration of serum visfatin among subjects with obesity was significantly higher those with normal weight subjects (10.39 ± 2.30 versus 6.9 ± 2.2 ng/mL; p < 0.001). The subjects with IR (10.58 ± 2.48 ng/mL ) had significantly higher visfatin concentration than those with IR- (10.58 ± 2.48 ng/mL and 8.47 ± 2.65 ng/mL) (p < 0.001, respectively). Visfatin positively correlated with BMI (r 0.627 and p < 0.001), WHR (r 0.203 and p 0.023), HOMA-IR (r 0.329 and p < 0.001), and hsCRP (r 0.421 and p < 0.001). Mean concentration of serum visfatin was not significantly different between groups of MetS and PreDM. Conclusion: Visfatin was associated with body mass index and insulin resistance, but not with metabolic syndrome and impaired glucose metabolism.en_US
dc.identifier.endpage67en_US
dc.identifier.issn2148-2357
dc.identifier.issn2148-2357
dc.identifier.issue2en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpBd01UWTFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/1335
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenel ve Dahili Tıpen_US
dc.titleEvaluation of Visfatin in Patients with Obesity, Metabolic Syndrome, Insulin Resistance and Impaired Glucose Tolerance; Case-Control Studyen_US
dc.typeArticleen_US

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