RELATIONSHIP BETWEEN SERUM ASYMMETRIC DIMETHYLARGININE LEVEL AND OBSTRUCTIVE SLEEP APNEA SYNDROME SEVERITY

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dc.contributor.authorSafcı, Sinem Berik
dc.contributor.authorCangür, Şengül
dc.contributor.authorArbak, Peri Meram
dc.contributor.authorBalbay, Ege Güleç
dc.contributor.authorAdmış, Özlem
dc.contributor.authorAydın, Leyla Yılmaz
dc.contributor.authorMemişoğulları, Ramazan
dc.date.accessioned2023-07-26T11:50:51Z
dc.date.available2023-07-26T11:50:51Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: The repetitive hypoxemia can induce oxidative stress mechanisms. Oxidative stress increases serum asymmetric dimethylarginine (ADMA) levels in patients with obstructive sleep apnea syndrome (OSAS). To in- vestigate the relationship between serumlevels of ADMA and OSAS severity. Methods: 330 patient’s records, who underwent overnight polysomnogra- phy (PSG) were retrospectively examined. The patients who had an abnor- mal serum glucose, lipid, thyroid, renal and liver function tests levels, had excluded. 72 patients had participating criteria. Patients were categorized into five groups according to apnea/hipopnea index (AHI). Measurement of ADMA levels were performed by ELISA kit. Results: The mean age was 44,19 ± 14,24 years. 31,9 % of the patients were female. Patients in normal group, severe, medium, mild and posi- tional–REM dependent OSAS group were 26,4%, 25%, 6,9 %, 16,7% and 25%; respectively. A significant positive correlation was found between AHI and ADMA (r= 0,483; p<0,001). Appropriate cut-off criterion was set at 1,39 for ADMA. Sensitivity for this value was 73,58 % (95 % Confidence Interval (CI): 61,71- % 85,45 %) and specificity was 94,74 % (95 % CI: 84,70- % to 100%). Accuracy or correct classification rate was found to be 79,17 %. The positive predictive value was 97,5 % and negative predictive value was 56,25 %. The positive likelihood ratio (LR +) was 13,98 (LR + > 10) and the negative likelihood ratio was (LR-) 0,28 (R- <1). Conclusions: ADMA was found to be a strong and good diagnostic tool among patients with normal levels for glucose, lipid, TSH, creatinine and liver function tests.en_US
dc.identifier.doi10.36516/jocass.2022.99
dc.identifier.endpage75en_US
dc.identifier.issn2667-498X
dc.identifier.issue1en_US
dc.identifier.startpage68en_US
dc.identifier.trdizinid1120580en_US
dc.identifier.urihttp://doi.org/10.36516/jocass.2022.99
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1120580
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12442
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorArbak, Peri Meram
dc.language.isoenen_US
dc.relation.ispartofÇukurova Anestezi ve Cerrahi Bilimler Dergisien_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectObstructive sleep apneaen_US
dc.subjecthypoxemiaen_US
dc.subjectADMA Obstrüktif uyku apne sendromuen_US
dc.subjecthipoksemien_US
dc.subjectADMAen_US
dc.titleRELATIONSHIP BETWEEN SERUM ASYMMETRIC DIMETHYLARGININE LEVEL AND OBSTRUCTIVE SLEEP APNEA SYNDROME SEVERITYen_US
dc.typeOtheren_US

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