Obezite polikliniğine başvuran hastalarda homa-ır ile trigliserid glukoz indeksi ve plazma aterojenik indeks ilişkisinin değerlendirilmesi
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
ÖZET Amaç: Bu çalışmada obezite polikliniğine başvuran hastalarda HOMA-IR ölçümünün Trigliserit Glukoz indeksi (TyG) ve Plazma Aterojenik İndeks (PAİ) ile olan ilişkisini karşılaştırmayı amaçladık. Yöntem: Bu çalışmaya Düzce Üniversitesi Aile Hekimliği Obezite polikliniğine 01.01.2022-31.12.2022 tarihleri arasında başvuran 205 hasta dahil edildi. Hastaların laboratuvar verileri kullanılarak HOMA-IR, TyG ve PAİ değerleri hesaplanarak birbirleriyle olan ilişkileri değerlendirildi. Bulgular: Çalışmamıza katılan 205 hastanın %78.5'ini kadınlar oluşturmaktaydı. Çalışmada hem kadınların hem de erkeklerin en fazla Evre 1 obez grupta olduğu saptandı. VKİ arttıkça kilo, AKŞ, LDL, insulin, HOMA-IR ve TyG değerlerinde anlamlı bir artış olduğu görüldü. HOMA-IR değerine göre insulin direnci olan grupta ölçülen kilo, VKİ, AKŞ, Trigliserit, İnsülin, TyG, PAİ değerleri diğer gruba göre anlamlı düzeyde daha yüksek saptandı (sırasıyla p<0.001, p<0.001, p<0.001, p=0.044, p<0.001, p=0.004, p=0.003). TyG indeksine göre insulin direnci olan grupta ölçülen yaş, AKŞ, LDL, T.Kolesterol, Trigliserit, İnsülin, HOMA-IR, PAİ değerleri diğer grupta ölçülen değerlerden anlamlı düzeyde daha yüksek bulundu (sırasıyla p=0.006, p=0.003, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001). PAİ'ne göre yüksek riskli olan grupta ölçülen LDL, T. Kolesterol, Trigliserit, HOMA-IR değerleri diğer gruplarda ölçülen değerlerinden anlamlı düzeyde daha yüksek saptandı (sırasıyla (p<0.001, p=0.008), (p<0.001, p=0.001), (p<0.001, p<0.001), (p=0.013, p=0.038)). Sonuç: Çalışmamızda yaygın olarak kullanılan insulin direnci belirteci olan HOMA-IR'nin yeni nesil TyG ve PAİ indeksleri ile bir korelasyon içinde olduğunu saptadık. Birinci basamak laboratuvar hizmeti verilen çoğu birimde insulin düzeyi ölçülemediği için TyG indeksi insulin direncini belirlemek için kullanılabilir. PAİ ile de hastaların kardiyometabolik riskleri kolaylıkla değerlendirilebilir. Anahtar Kelimeler: Obezite, HOMA-IR, Trigliserit Glukoz indeksi, Plazma Aterojenik İndeks
ABSTRACT Objective: In this study, it was aimed to compare the relationship between HOMA-IR measurement and Triglyceride Glucose index (TyG) and Plasma Atherogenic Index (PAI) in patients admitted to the obesity outpatient clinic. Method: 205 patients who applied to Düzce University Family Medicine Obesity Polyclinic between 01.01.2022 and 31.12.2022 were included in this study. HOMA-IR, TyG and PAI values were calculated using the laboratory data of the patients and their relations with each other were evaluated. Results: 205 patients were involved in our study, and 78.5% of them were female. It was determined that both women and men were mostly in the Stage 1 obese group. It was observed that there was a significant increase in weight, FPG, LDL, insulin, HOMA-IR and TyG values as BMI increased. According to the HOMA-IR value, the weight, BMI, FPG, Triglyceride, Insulin, TyG, and PAI values measured in the group with insulin resistance were found to be significantly higher than the other group (p<0.001, p<0.001, p<0.001, p=0.044, p<0.001, p=0.004, p=0.003 respectively). Age, FPG, LDL, T. Cholesterol, Triglyceride, Insulin, HOMA-IR, PAI values measured in the insulin resistance group according to the TyG index were significantly higher than the values measured in the other group (p=0.006, p=0.003, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001 respectively). LDL, T. Cholesterol, Triglyceride, HOMA-IR values measured in the high-risk group according to PAI were found to be significantly higher than the values measured in the other groups ((p<0.001, p=0.008), (p<0.001, p=0.001), (p<0.001, p<0.001), (p=0.013, p=0.038) respectively). Conclusion: In our study, we found that HOMA-IR, which is a widely used indicator of insulin resistance in accordance with the literature, is in a correlation with the new generation TyG and PAI indices. The situation where insulin resistance cannot be determined due to the inability to measure the insulin level in most units where primary laboratory services are provided can be eliminated by using the TyG index, and the cardiometabolic risks of the patients can be easily evaluated with PAI. Keywords: Obesity, HOMA-IR, Triglyceride Glucose index, Plasma Atherogenic Index
ABSTRACT Objective: In this study, it was aimed to compare the relationship between HOMA-IR measurement and Triglyceride Glucose index (TyG) and Plasma Atherogenic Index (PAI) in patients admitted to the obesity outpatient clinic. Method: 205 patients who applied to Düzce University Family Medicine Obesity Polyclinic between 01.01.2022 and 31.12.2022 were included in this study. HOMA-IR, TyG and PAI values were calculated using the laboratory data of the patients and their relations with each other were evaluated. Results: 205 patients were involved in our study, and 78.5% of them were female. It was determined that both women and men were mostly in the Stage 1 obese group. It was observed that there was a significant increase in weight, FPG, LDL, insulin, HOMA-IR and TyG values as BMI increased. According to the HOMA-IR value, the weight, BMI, FPG, Triglyceride, Insulin, TyG, and PAI values measured in the group with insulin resistance were found to be significantly higher than the other group (p<0.001, p<0.001, p<0.001, p=0.044, p<0.001, p=0.004, p=0.003 respectively). Age, FPG, LDL, T. Cholesterol, Triglyceride, Insulin, HOMA-IR, PAI values measured in the insulin resistance group according to the TyG index were significantly higher than the values measured in the other group (p=0.006, p=0.003, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001, p<0.001 respectively). LDL, T. Cholesterol, Triglyceride, HOMA-IR values measured in the high-risk group according to PAI were found to be significantly higher than the values measured in the other groups ((p<0.001, p=0.008), (p<0.001, p=0.001), (p<0.001, p<0.001), (p=0.013, p=0.038) respectively). Conclusion: In our study, we found that HOMA-IR, which is a widely used indicator of insulin resistance in accordance with the literature, is in a correlation with the new generation TyG and PAI indices. The situation where insulin resistance cannot be determined due to the inability to measure the insulin level in most units where primary laboratory services are provided can be eliminated by using the TyG index, and the cardiometabolic risks of the patients can be easily evaluated with PAI. Keywords: Obesity, HOMA-IR, Triglyceride Glucose index, Plasma Atherogenic Index
Açıklama
Anahtar Kelimeler
Aile Hekimliği, Family Medicine
