Do Pediatric Patients with Familial Mediterranean Fever who have Phenotypically Predominant Arthritis, Arthralgia, and Myalgia Reflect a More Serious Underlying Disease than Those with Phenotypically Predominant Abdominal Pain?

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dc.contributor.authorBeşeren, Tuğba Nur Kutlu
dc.contributor.authorErgüven, Müferet
dc.contributor.authorÜstebay, Sefer
dc.date.accessioned2025-03-24T19:50:45Z
dc.date.available2025-03-24T19:50:45Z
dc.date.issued2024
dc.departmentDüzce Üniversitesi
dc.description.abstractAim: The study aimed to determine the presence of different demographic, familial, clinical, laboratory, and genotypic characteristics between children with Familial Mediterranean Fever (FMF) with recurrent arthritis, arthralgia, and myalgia phenotype and children with FMF with recurrent abdominal attacks phenotype. Material and Method: The study included patients who were admitted to the Pediatric Rheumatology Outpatient Clinic of the Kafkas University Research Hospital before 2020, who were diagnosed with FMF and followed up for at least 1 year, and who were diagnosed with clinically recurrent arthritis, arthralgia, myalgia, and recurrent abdominal pain. Patients were divided into two groups: 151 patients with recurrent arthritis, arthralgia, and myalgia with FMF phenotypic features (Group 1) and 102 patients with recurrent diffuse, incomplete peritoneal involvement with predominant FMF phenotypic features (Group 2). The demographic and familial characteristics, age at diagnosis, and other clinical, laboratory, and genetic features of these 2 groups were compared, and the differences were statistically evaluated. Results: While 60.6% of the patients in Group 1 and 39.4% in Group 2 were female, 58.7% of the patients in Group 1 and 41.3% in Group 2 were male. No significant statistical difference was found between the two groups. When the groups were compared regarding genetic mutations, M694V homozygotes were observed in 17.2% of Group 1 and 8.8% of Group 2. There was a statistically significant difference between Group 1 and Group 2 in M694V homozygotes (p
dc.identifier.endpage289
dc.identifier.issn2146-2631
dc.identifier.issn2587-053X
dc.identifier.issue3
dc.identifier.startpage284
dc.identifier.urihttps://hdl.handle.net/20.500.12684/20073
dc.identifier.volume14
dc.language.isoen
dc.publisherKafkas University
dc.relation.ispartofKafkas Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250324
dc.subjectfamilial Mediterranean fever|arthritis|arthralgia|myalgia|involvement
dc.titleDo Pediatric Patients with Familial Mediterranean Fever who have Phenotypically Predominant Arthritis, Arthralgia, and Myalgia Reflect a More Serious Underlying Disease than Those with Phenotypically Predominant Abdominal Pain?
dc.typeArticle

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